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Updated: Jul 5, 2025

A Novel Method: Super-selective Adrenal Venous Sampling
Published on: September 15, 2017
Pituitary Macroadenoma With Macronodular Adrenal Hyperplasia and Novel Armadillo Repeat-Containing Protein 5 (ARMC5)
Shikha Khosla1,2, Farah Alsarraf3, Eric S Nylen1,2
1Division of Endocrinology, Veterans Affairs Medical Center, Washington, DC 20422, USA.
Abstract:
We present an unusual case of primary bilateral macronodular adrenal hyperplasia (PBMAH) in a 72-year-old African American man. The patient was found to harbor massively enlarged bilateral adrenal glands on imaging along with mild autonomous cortisol secretion. His workup for PBMAH included leukocyte analysis for the armadillo repeat-containing protein 5 (ARMC5) gene. The test revealed a novel heterozygous somatic ARMC5 mutation. The patient was initially managed conservatively. He subsequently presented with unprovoked bilateral pulmonary emboli. This was followed by the discovery of a nonsecreting pituitary macroadenoma, a hitherto unreported but putative association.
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