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Updated: Jun 23, 2026
Calcification of Vascular Smooth Muscle Cells and Imaging of Aortic Calcification and Inflammation
Published on: May 31, 2016
Effect of chronic kidney disease induced calcification on peripheral vascular perfusion using near-infrared
Daniela Leizaola1,2, Valentina Dargam3, Kevin Leiva1
1Optical Imaging Laboratory, Biomedical Engineering Department, 10555 W Flagler St, Miami, FL 33174, USA.
Abstract:
Low-cost techniques that can detect the presence of vascular calcification (VC) in chronic kidney disease (CKD) patients could improve clinical outcomes. In this study, we established a near-infrared spectroscopy-based imaging technique to determine changes in peripheral hemodynamics due to CKD-induced VC. Mice were fed a high-adenine diet with either normal or high levels of phosphate to induce CKD with and without VC, respectively. The mice tail was imaged to evaluate hemodynamic changes in response to occlusion. The rate of change in oxyhemoglobin in response to occlusion showed a statistically significant difference in the presence of VC in the mice.
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