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Long-term aspirin use in patients hospitalized with ischemic colitis
Humzah Iqbal1, Rakahn Haddadin2, Patrick Zhang3
1Department of Internal Medicine, University of California San Francisco, Fresno, CA (Humzah Iqbal).
Insights
Long-term aspirin use in patients with ischemic colitis was linked to reduced mortality and fewer complications. This finding suggests aspirin may improve outcomes for this condition, impacting patient recovery and healthcare costs.
Area of Science:
- Gastroenterology
- Vascular Medicine
- Clinical Pharmacology
Background:
- Ischemic colitis is a gastrointestinal condition often affecting patients with pre-existing vascular disease.
- Aspirin is known to benefit cardiovascular and cerebrovascular disease patients, but its role in ischemic colitis is not well-defined.
Purpose of the Study:
- To investigate the association between long-term aspirin use and clinical outcomes in patients hospitalized with ischemic colitis.
Main Methods:
- A retrospective analysis of the 2020 Nationwide Inpatient Sample identified patients diagnosed with ischemic colitis.
- Patient data were stratified based on long-term aspirin use, and multivariate regression analyzed outcomes including mortality, complications, length of stay, and hospital charges.
Main Results:
- Long-term aspirin use was associated with significantly lower in-hospital mortality, bowel perforation, peritonitis, shock, and blood transfusion rates.
- Aspirin users experienced a shorter mean length of stay (6.1 days vs. 9.4 days) and lower mean hospital charges ($87,123 vs. $161,610).
Conclusions:
- Long-term aspirin use in patients hospitalized with ischemic colitis correlates with a reduced risk of mortality and adverse events.
- These findings highlight a potential protective effect of aspirin in managing ischemic colitis, leading to improved patient outcomes and reduced healthcare utilization.
Background:
Ischemic colitis is a form of mesenteric ischemia that often presents in patients with vascular disease. Long-term aspirin use has been shown to improve the outcomes in patients with cardiovascular or cerebrovascular disease. However, the relationship between aspirin use and ischemic colitis is unclear.
Methods:
Patients with a diagnosis of ischemic colitis were identified using the 2020 Nationwide Inpatient Sample. Patients were stratified by long-term aspirin use at the time of hospitalization. Data were collected regarding mortality, bowel perforation, peritonitis, shock, blood transfusion, length of stay in days (LOS), hospital charges, age, sex, race, primary insurance, median income, hospital region, hospital size, and comorbidities. The relationship between aspirin use and outcomes was analyzed using multivariate regression analysis.
Results:
A total of 67,685 patients were included. Aspirin users had a mean age of 72.8 years compared to 66.8 years for non-aspirin users. Long-term aspirin use was associated with a lower risk of in-hospital mortality (P<0.001), bowel perforation (P<0.001), peritonitis (P=0.01), shock (P<0.001), and blood transfusion (P<0.001). The mean LOS was 6.1 days in the aspirin group compared to 9.4 days in the non-aspirin group. Ischemic colitis patients taking aspirin had a mean hospitalization charge of $87,123 compared to $161,610 for those not using aspirin.
Conclusions:
Our study examined the impact of aspirin use in ischemic colitis patients. Among patients hospitalized with ischemic colitis, we found that long-term aspirin use was associated with a lower risk of in-hospital mortality and adverse events.
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