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Related Experiment Video

Updated: Jul 5, 2025

Generation and Multi-phenotypic High-content Screening of Coxiella burnetii Transposon Mutants
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Large-Vessel Vasculitis and Q Fever Correlation.

Joana C Ramos1, Daniela Santos1, Patrícia Dias1

  • 1Internal Medicine Department, Centro Hospitalar e Universitário de Coimbra (CHUC), Coimbra, Portugal.

European Journal of Case Reports in Internal Medicine
|January 15, 2024
PubMed
Summary

Acute Q fever, a zoonotic infection, can trigger large-vessel vasculitis. This rare immunologic response involves major arteries and requires further study for effective management strategies.

Keywords:
FDG-PET/CT scanLarge-vessel vasculitisQ fever

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Area of Science:

  • Infectious Diseases
  • Immunology
  • Cardiology

Background:

  • Q fever is a zoonotic infection caused by Coxiella burnetii.
  • Clinical manifestations vary widely based on acute or chronic infection.
  • Large-vessel vasculitis is an uncommon complication.

Purpose of the Study:

  • To report a rare case of acute Q fever presenting with large-vessel vasculitis.
  • To highlight the potential immunologic response in Q fever.
  • To contribute to the limited data on managing this condition.

Main Methods:

  • Case presentation of a 61-year-old male with a month of symptoms.
  • Extensive diagnostic workup including FDG-PET/CT scan.
  • Diagnosis of acute Q fever with associated large-vessel vasculitis.

Main Results:

  • The patient presented with fatigue, thoracalgia, fever, night sweats, and weight loss.
  • FDG-PET/CT revealed active vasculitis in the thoracic aorta, abdominal aorta, subclavian, and carotid vessels.
  • The findings suggest an immunologic response to acute Q fever.

Conclusions:

  • Large-vessel vasculitis can be an immunologic manifestation of acute Q fever.
  • There is a scarcity of data regarding the treatment and management of Q fever-related large-vessel vasculitis.