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Single-cell multi-omics in the study of digestive system cancers
Shuang Zhou1,2, Nanfei Lin2, Liying Yu2
1The Second Clinical Medical School of Fujian Medical University, Quanzhou, Fujian Province, China.
Computational and Structural Biotechnology Journal
|January 15, 2024
Summary
Single-cell sequencing (SCS) advances, including multi-omics and spatial transcriptomics, offer new insights into digestive system cancers. These technologies address challenges like tumor heterogeneity and drug resistance, improving diagnosis and treatment strategies.
Area of Science:
- Oncology
- Genomics
- Biotechnology
Background:
- Digestive system cancers present significant public health challenges due to high mortality and economic impact.
- Conventional treatments face hurdles like tumor heterogeneity and drug resistance.
Purpose of the Study:
- To comprehensively review advances in single-cell omics technologies for studying digestive system tumors.
- To analyze research cases, detailing sequencing platforms, sample information, and key findings.
Main Methods:
- Review of single-cell sequencing (SCS) technologies, from scRNA-seq to single-cell multi-omics and spatial transcriptomics (ST).
- Analysis of published research cases, extracting data on platforms, samples, methods, and outcomes.
Main Results:
- Detailed summary of commonly used SCS platforms and their characteristics.
- Highlighting the advantages of integrating multi-omics data for a deeper understanding of digestive system cancers.
Conclusions:
- Single-cell multi-omics technologies are crucial for advancing digestive system cancer research.
- Future prospects indicate continued development and application of these powerful tools in oncology.
