Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Cardiac Action Potential01:30

Cardiac Action Potential

1.4K
Cardiac action potentials are essential for proper heart function, enabling the rhythmic contractions needed for adequate blood circulation. Nodal cells and Purkinje fibers, specialized for electrical conduction, generate these action potentials.
The cardiac action potential process involves a series of phases characterized by the movement of ions across the cardiac cell membranes, leading to the depolarization and repolarization of the cardiac myocytes.
Ionic Basis of Cardiac Action Potentials
1.4K
Mechanism of Cardiac Arrhythmias01:28

Mechanism of Cardiac Arrhythmias

922
Arrhythmias are irregular heart rhythms occurring when the heart's electrical impulses become abnormal. These disturbances can lead to various symptoms, depending on their severity and the underlying cause. Some common factors contributing to arrhythmias include hypoxia, ischemia, electrolyte imbalances, excessive catecholamine exposure, drug toxicity, and muscle overstretching. Arrhythmias can be classified into two main types based on the rate and site of origin of abnormal heart rhythms.
922
Disturbances in Heart Rhythm01:28

Disturbances in Heart Rhythm

961
Arrhythmia or dysrhythmia refers to an abnormal heart rhythm caused by a defect in the heart's conduction system. It can cause the heart to beat irregularly, too quickly, or too slowly, leading to symptoms like chest pain, shortness of breath, and fainting. Factors such as stress, caffeine, alcohol, nicotine, cocaine, certain drugs, congenital defects, diseases, and electrolyte abnormalities can trigger arrhythmias.
Arrhythmias are categorized by their speed, rhythm, and origin. A slow...
961
Arteries of the Lower Limbs01:24

Arteries of the Lower Limbs

190
Epilepsy is a chronic neurological disease marked by recurrent, unpredictable seizures. These seizures are caused by abnormal electrical discharges in the brain, leading to behavior, sensation, or consciousness alterations. They can also cause transient impairment of awareness, interfering with daily activities.
Various factors can trigger epilepsy, including genetic factors, brain damage, metabolic causes, and unknown etiology. Diagnosis of epilepsy involves electroencephalography (EEG), which...
190
Seizures: Classification01:13

Seizures: Classification

365
Epilepsy is primarily characterized by unpredictable seizures, either provoked by an identifiable factor, such as injury or illness, or unprovoked, occurring spontaneously without apparent cause.
Seizures are typically classified into two main categories: focal and generalized seizures.
Focal Seizures
Focal seizures originate from specific regions of the brain. These seizures are further sub-classified into two types:
365
ECG Interpretation of Arrhythmias I: Sinus Arrhythmias01:16

ECG Interpretation of Arrhythmias I: Sinus Arrhythmias

216
Arrhythmias are disturbances in the heart's rhythm that lead to abnormal heartbeats. These irregularities can originate from different parts of the heart and are classified based on their origin and nature.
Types of Arrhythmias
Sinus Node Arrhythmias
Sinus Bradycardia: Originating from the sinoatrial (SA) node, sinus bradycardia involves slower impulses, resulting in a heart rate of less than 60 beats per minute (bpm). Causes include sleep, vagal stimulation, beta-blockers, hypothyroidism,...
216

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Cerebral venous thrombosis-related stroke in India: Clinical patterns, risk factors, and outcomes from the hospital-based stroke registry programme.

The Indian journal of medical research·2026
Same author

ECHO-T2D - economic, clinical epidemiologic, and humanistic profiling of diabetic retinopathy, diabetic kidney disease, and painful diabetic peripheral neuropathy in India: A systematic review protocol.

MethodsX·2026
Same author

Left Bundle Branch Area Pacing After Cone Repair for Ebstein's Anomaly.

JACC. Case reports·2026
Same author

Etomidate is a potential medical option in the management of severe and refractory Cushing's syndrome.

Journal of anaesthesiology, clinical pharmacology·2026
Same author

Patient profiles and disease characteristics of the IMSRN cohort: a multicentre study (2021-2025).

The Lancet regional health. Southeast Asia·2026
Same author

Comparison of Analgesic Efficacy of Intrathecal Morphine and Ultrasound-Guided Bilateral Erector Spinae Plane Block in Patients Undergoing Open Heart Surgery with Midline Sternotomy: An Open Label Randomized Control Trial.

Annals of cardiac anaesthesia·2026

Related Experiment Video

Updated: Jul 5, 2025

Methods for ECG Evaluation of Indicators of Cardiac Risk, and Susceptibility to Aconitine-induced Arrhythmias in Rats Following Status Epilepticus
08:28

Methods for ECG Evaluation of Indicators of Cardiac Risk, and Susceptibility to Aconitine-induced Arrhythmias in Rats Following Status Epilepticus

Published on: April 5, 2011

17.8K

Cardiac Abnormalities in Refractory Status Epilepticus-an Exploratory Study.

Deepika Saroha1, Samhita Panda1, Surender Deora2

  • 1Department of Neurology, All India Institute of Medical Sciences (AIIMS), Jodhpur, India.

Journal of Epilepsy Research
|January 15, 2024
PubMed
Summary

Cardiac abnormalities and reduced heart rate variability (HRV) are linked to poor outcomes in refractory status epilepticus (RSE). Early cardiac assessment using ECG and echocardiography can help predict prognosis in RSE patients.

Keywords:
Cardiac injuryHeart rate variabilityNT-proBNPStatus epilepticusTroponin-T

More Related Videos

Multi-system Monitoring for Identification of Seizures, Arrhythmias and Apnea in Conscious Restrained Rabbits
10:25

Multi-system Monitoring for Identification of Seizures, Arrhythmias and Apnea in Conscious Restrained Rabbits

Published on: March 27, 2021

6.0K
Implantation of Electroencephalogram and Electrocardiogram Telemetry Devices in Neonatal Rabbit Kits
06:46

Implantation of Electroencephalogram and Electrocardiogram Telemetry Devices in Neonatal Rabbit Kits

Published on: February 28, 2025

263

Related Experiment Videos

Last Updated: Jul 5, 2025

Methods for ECG Evaluation of Indicators of Cardiac Risk, and Susceptibility to Aconitine-induced Arrhythmias in Rats Following Status Epilepticus
08:28

Methods for ECG Evaluation of Indicators of Cardiac Risk, and Susceptibility to Aconitine-induced Arrhythmias in Rats Following Status Epilepticus

Published on: April 5, 2011

17.8K
Multi-system Monitoring for Identification of Seizures, Arrhythmias and Apnea in Conscious Restrained Rabbits
10:25

Multi-system Monitoring for Identification of Seizures, Arrhythmias and Apnea in Conscious Restrained Rabbits

Published on: March 27, 2021

6.0K
Implantation of Electroencephalogram and Electrocardiogram Telemetry Devices in Neonatal Rabbit Kits
06:46

Implantation of Electroencephalogram and Electrocardiogram Telemetry Devices in Neonatal Rabbit Kits

Published on: February 28, 2025

263

Area of Science:

  • Neurology
  • Cardiology
  • Critical Care Medicine

Background:

  • Refractory status epilepticus (RSE) is associated with cardiac abnormalities.
  • Reduced heart rate variability (HRV) and arrhythmias may contribute to sudden unexpected death in epilepsy.
  • Cardiac changes in RSE can impact prognosis and functional outcomes.

Purpose of the Study:

  • To investigate the utility of electrocardiographic and echocardiographic changes in predicting RSE prognosis.
  • To explore the correlation between cardiac abnormalities and functional outcomes in RSE patients.

Main Methods:

  • Prospective observational study of 20 RSE patients.
  • Electrocardiogram (ECG), Holter monitoring, troponin-I (Trop I), NT-proBNP, and 2D echocardiography (2D Echo) were performed.
  • Cardiac parameters, HRV, and QTc intervals were assessed at baseline, discharge, and 30 days post-discharge.

Main Results:

  • Common etiologies for RSE included CNS infection, autoimmune encephalitis, and cerebrovascular disease.
  • Cardiac enzyme elevation and QTc prolongation were frequent abnormalities.
  • Reduced HRV and cardiac injury markers correlated significantly with poor outcomes (poor GCS, mRS) and non-convulsive status epilepticus (NCSE).

Conclusions:

  • Poor Glasgow Coma Scale (GCS), modified Rankin Scale (mRS), cardiac injury markers, reduced HRV, and NCSE are consistent predictors of mortality and poor clinical outcomes in RSE.
  • Routine, non-invasive cardiac assessments (ECG, 2D Echo, Holter, NT-proBNP, Trop I) are recommended for RSE patients.