Dual-Energy Cone-Beam CT with Three-Material Decomposition for Bone Marrow Edema Imaging

We investigate the feasibility of bone marrow edema (BME) detection using a kV-switching Dual-Energy (DE) Cone-Beam CT (CBCT) protocol. This task is challenging due to unmatched x-ray paths in the low-energy (LE) and high-energy (HE) spectral channels, CBCT non-idealities such as x-ray scatter, and narrow spectral separation between fat (bone marrow) and water (BME). We propose a comprehensive DE decomposition framework consisting of projection interpolation onto matching LE and HE view angles, fast Monte Carlo scatter correction with low number of tracked photons and Gaussian denoising, and two-stage three-material decompositions involving two-material (fat-Aluminium) Projection-Domain Decomposition (PDD) followed by image-domain three-material (fat-water-bone) base-change. Performance in BME detection was evaluated in simulations and experiments emulating a kV-switching CBCT wrist imaging protocol on a robotic x-ray system with 60 kV LE beam, 120 kV HE beam, and 0.5° angular shift between the LE and HE views. Cubic B-spline interpolation was found to be adequate to resample HE and LE projections of a wrist onto common view angles required by PDD. The DE decomposition maintained acceptable BME detection specificity (<0.2 mL erroneously detected BME volume compared to 0.85 mL true BME volume) over +/-10% range of scatter magnitude errors, as long as the scatter shape was estimated without major distortions. Physical test bench experiments demonstrated successful discrimination of ~20% change in fat concentrations in trabecular bone-mimicking solutions of varying water and fat content.