Surface-modified titanium and titanium-based alloys for improved osteogenesis: A critical review

Area of Science:

• Biomaterials Science
• Orthopedic Engineering
• Dental Implantology

Background:

• Titanium and its alloys are widely used for dental and orthopedic implants.
• Current titanium implants show limited osteogenic potential, leading to poor bone integration.
• Surface modifications and loaded components can enhance peri-implant bone regeneration.

Purpose of the Study:

• To review the use of osteogenesis components on titanium implants.
• To emphasize surface modification techniques and drug release efficacy.
• To discuss future prospects for improving peri-implant bone formation.

Main Methods:

• Literature review of studies on titanium implant surface modification.
• Analysis of osteogenesis components loaded onto titanium and its alloys.
• Evaluation of different surface-modification strategies and their efficacy.

Main Results:

• Surface topology and composition optimization significantly promote bone regeneration.
• Various osteogenesis components can be loaded onto titanium surfaces.
• Surface modification methods influence the release of loaded substances.

Conclusions:

• Further research should focus on novel loading components for titanium implants.
• Innovative surface modification methods are crucial for enhanced bone formation.
• Developing sustained-release systems on implant surfaces is key for improved outcomes.