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Updated: Jul 5, 2025
Reproductive Techniques for Ovarian Monitoring and Control in Amphibians
Published on: May 12, 2019
Sublingual human chorionic gonadotropin as an adjuvant to ovulation induction
Paula Almeida Galvão Ferreira1, Luiz Augusto Giordano1, Luiz Felipe Bittencourt2
1Departamento de Ginecologia, Universidade Federal do Estado do Rio de Janeiro, Rio de Janeiro, RJ, Brazil.
Objective:
To evaluate the efficacy of sublingually administered human chorionic gonadotropin (HCG) in combination with clomiphene citrate (CC) or letrozole (LTZ) for ovulation induction.
Methods:
In this prospective, double-blind, randomized study, the patients were divided into two placebo groups and two intervention groups using CC, LTZ, and HCG.
Results:
There were no statistically significant differences in ovulation induction between the groups. We compared endometrial thickness at the beginning of the cycle and during the pre-ovulatory period, and detected a moderately positive correlation when CC was administered with HCG.
Conclusions:
Sublingual HCG with CC caused a moderately positive correlation with endometrial thickening when compared with that at the beginning of the cycle and during the pre-ovulatory period. There was no significant change in the number of pre-ovulatory follicles.
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