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The Goeckerman Regimen for the Treatment of Moderate to Severe Psoriasis
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[Translated aticle] Topical and Oral Roflumilast in Dermatology: A Narrative Review
M Mansilla-Polo1, E Gimeno2, D Morgado-Carrasco3
1Servicio de Dermatología, Hospital Universitario y Politécnico La Fe, Valencia, Spain; Instituto de Investigación Sanitaria La Fe (IIS La Fe), Valencia, Spain.
Actas Dermo-Sifiliograficas
|January 15, 2024
Summary
Roflumilast, a phosphodiesterase-4 inhibitor, shows promise in dermatology for treating conditions like psoriasis and seborrheic dermatitis. Its favorable safety profile and cost-effectiveness make it a valuable therapeutic option.
Area of Science:
- Dermatology
- Pharmacology
Background:
- Oral roflumilast is approved for COPD exacerbations.
- Topical roflumilast treats plaque psoriasis and seborrheic dermatitis.
- Off-label dermatological uses are increasingly reported.
Purpose of the Study:
- To review the pharmacokinetics and pharmacodynamics of roflumilast.
- To discuss approved and off-label dermatological applications.
- To evaluate the safety and cost-effectiveness of roflumilast.
Main Methods:
- Literature review of published studies on roflumilast in dermatology.
- Analysis of pharmacokinetic and pharmacodynamic data.
- Assessment of safety profiles and cost comparisons.
Main Results:
- Roflumilast demonstrates efficacy in plaque psoriasis and seborrheic dermatitis.
- Off-label uses show potential in hidradenitis suppurativa, aphthosis, eczema, lichen planus, and Behçet disease.
- Favorable safety profile comparable to apremilast and cost-effectiveness.
Conclusions:
- Roflumilast is a promising agent for various dermatological conditions.
- Its established safety and economic advantages support its consideration.
- Further research into off-label uses is warranted.
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