Related Experiment Video
Updated: Jul 5, 2025
05:23
Visualization of SARS-CoV-2 using Immuno RNA-Fluorescence In Situ Hybridization
Published on: December 23, 2020
6.1K
SARS-CoV-2 biology and host interactions.
Silvio Steiner1,2, Annika Kratzel1,2, G Tuba Barut1,2
1Institute of Virology and Immunology, Bern and Mittelhäusern, Bern, Switzerland.
Nature Reviews. Microbiology
|January 15, 2024
Summary
This review summarizes the SARS-CoV-2 life cycle, gene function, and virus-host interactions. It highlights new findings on coronavirus biology and host factors crucial for virus replication, aiding in understanding COVID-19 pathogenesis.
Area of Science:
- Virology
- Molecular Biology
- Infectious Diseases
Background:
- The zoonotic emergence of SARS-CoV-2 caused the COVID-19 pandemic, impacting global health.
- Continuous evolution of SARS-CoV-2 variants poses ongoing public health threats.
- Understanding virus-host interactions is key to combating viral infections.
Purpose of the Study:
- To provide an updated summary of the SARS-CoV-2 life cycle.
- To review gene function and virus-host interactions.
- To highlight recent discoveries in coronavirus biology and host factors.
Main Methods:
- Literature review of recent scientific advances.
- Analysis of large-scale screens for host-cell factors.
- Synthesis of findings on molecular and cellular mechanisms.
Main Results:
- Detailed overview of the SARS-CoV-2 replication cycle.
- Identification of essential host-cell factors for virus propagation.
- Elucidation of key virus-host interactions.
Conclusions:
- Recent research has significantly advanced our understanding of SARS-CoV-2.
- Novel host factors are critical for viral replication and represent potential therapeutic targets.
- Continued research is vital for managing the ongoing threat of SARS-CoV-2 and future pandemics.
More Related Videos
Related Concept Videos
01:03Rous Sarcoma Virus (RSV) and Cancer
5.1K
Rous Sarcoma virus or RSV was discovered by F. Peyton Rous in the year 1911 as a filterable transmissible agent that could cause tumors in chickens. He won a Nobel Prize for this discovery in 1966. His experiments clearly demonstrated that some cancers could be caused by infectious agents and led to the discovery of many more cancer-causing viruses in animals as well as humans.
RSV is a retrovirus that contains two copies of a plus-strand RNA genome. Its genome consists of four main open...
RSV is a retrovirus that contains two copies of a plus-strand RNA genome. Its genome consists of four main open...
5.1K
01:05Single Nucleotide Polymorphisms-SNPs
15.1K
A single nucleotide polymorphism or SNP is a single nucleotide variation at a specific genomic position in a large population. It is the most prevalent type of sequence variation found in the human genome. Point mutations that occur in more than 1% of the population qualify as SNPs. These are present once every 1000 nucleotides on an average in the human genome. Replacement of a purine with another purine (A/G) or a pyrimidine with another pyrimidine (C/T) is known as a transition. In contrast,...
15.1K
02:50Conjugated Proteins
18.3K
Simple proteins and protein complexes contain only amino acids. In contrast, many other proteins, called conjugated proteins, covalently bond with non-protein moieties.
Nucleoproteins are protein complexes that contain nucleic acids, categorized as deoxyribonucleoproteins (DNPs) or ribonucleoproteins (RNPs) respectively. The nucleosome is a typical example of a DNP where nuclear DNA is associated with histone proteins. The major antigen for the Covid-19 virus SARS-CoV is an RNP that is critical...
Nucleoproteins are protein complexes that contain nucleic acids, categorized as deoxyribonucleoproteins (DNPs) or ribonucleoproteins (RNPs) respectively. The nucleosome is a typical example of a DNP where nuclear DNA is associated with histone proteins. The major antigen for the Covid-19 virus SARS-CoV is an RNP that is critical...
18.3K
00:57Viral Recombination
23.4K
Cells are sometimes infected by more than one virus at once. When two viruses disassemble to expose their genomes for replication in the same cell, similar regions of their genomes can pair together and exchange sequences in a process called recombination. Alternatively, viruses with segmented genomes can swap segments in a process called reassortment.
23.4K
01:20Infection
8.0K
When a pathogen enters the body and reproduces, it can cause an infection, damage body cells, and cause illness symptoms that eventually lead to disease. Therefore, its prevention requires breaking the chain of infection.
The chain begins with pathogens: bacteria, viruses, fungi, prions, or parasites such as protozoa helminths. These can be present on the skin as transient or resident flora, or they can be acquired from the environment. Identifying and treating the type of infection and...
The chain begins with pathogens: bacteria, viruses, fungi, prions, or parasites such as protozoa helminths. These can be present on the skin as transient or resident flora, or they can be acquired from the environment. Identifying and treating the type of infection and...
8.0K
01:10Retrovirus Life Cycles
46.0K
Retroviruses have a single-stranded RNA genome that undergoes a special form of replication. Once the retrovirus has entered the host cell, an enzyme called reverse transcriptase synthesizes double-stranded DNA from the retroviral RNA genome. This DNA copy of the genome is then integrated into the host’s genome inside the nucleus via an enzyme called integrase. Consequently, the retroviral genome is transcribed into RNA whenever the host’s genome is transcribed, allowing the...
46.0K