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Corpus callosum long-term biometry in very preterm children related to cognitive and motor outcomes

Manuel Lubián-Gutiérrez1,2, Isabel Benavente-Fernández3,4,5, Yolanda Marín-Almagro6

  • 1Division of Neurology, Department of Paediatrics, Puerta del Mar University Hospital, Cádiz, Spain.

Pediatric Research
|January 15, 2024
PubMed

Insights

Corpus callosum (CC) biometry in school-aged children born very preterm is linked to neurological outcomes. Posterior CC measurements show promise as a neurodevelopmental biomarker for very preterm infants.

Area of Science:

  • Neuroscience
  • Developmental Pediatrics
  • Radiology

Background:

  • The corpus callosum (CC) is a key white matter structure.
  • White matter integrity is often compromised in preterm birth.
  • Diagnosing mild white matter injury in preterm infants can be challenging.

Purpose of the Study:

  • To investigate the association between corpus callosum (CC) biometry and neurodevelopmental outcomes in school-aged children born very preterm.
  • To identify specific CC subregions that may serve as biomarkers for white matter integrity and neurological outcomes.

Main Methods:

  • 124 children born preterm underwent MRI for CC measurements.
  • Cognitive and motor functions were assessed using the Wechsler Intelligence Scale for Children-V (WPPSI-V) and Movement Assessment Battery for Children-2 (MABC-2).

Main Results:

  • Children with normal outcomes had greater CC height and total length compared to those with adverse outcomes.
  • Posterior CC measurements demonstrated high specificity in predicting neurological outcomes.
  • CC length and splenium height correlated with manual dexterity and overall motor scores.

Conclusions:

  • Corpus callosum (CC) biometry at school age is associated with neurodevelopmental outcomes in children born very preterm.
  • Specific alterations in CC subregions are observed in this population.
  • The posterior CC shows potential as a reliable neurodevelopmental biomarker for very preterm infants.
Abstract

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