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Updated: Jul 5, 2025
A Mouse Model for Vascular Cognitive Impairment and Dementia Based on Needle-guided Asymmetric Bilateral Common Carotid Artery Stenosis
Published on: November 22, 2024
National and international collaborations to advance research into vascular contributions to cognitive decline
Danit G Saks1, Eric E Smith2, Perminder S Sachdev1,3
1Centre for Healthy Brain Ageing, Discipline of Psychiatry and Mental Health, School of Clinical Medicine, University of New South Wales, Sydney, New South Wales, Australia.
Insights
Vascular contributions to cognitive impairment and dementia (VCID) research is advancing through 24 large-scale collaborations. These global efforts aim to understand and treat cognitive disorders caused by cerebrovascular disease.
Area of Science:
- Neurology
- Neuroscience
- Public Health
Background:
- Cerebrovascular disease is the second leading cause of cognitive disorders, contributing to approximately 70% of all dementias.
- Research in vascular contributions to cognitive impairment and dementia (VCID) has historically lagged behind Alzheimer's disease research.
- There is a growing recognition that significant progress in VCID research necessitates large-scale national and international collaborations.
Purpose of the Study:
- To highlight 24 major national and international initiatives focused on advancing VCID research.
- To outline the objectives of these collaborations, including investigating cognitive effects, mechanisms, prevention, and treatment of VCID.
- To emphasize the trend towards global collaboration and data sharing in VCID research.
Main Methods:
- Review and summary of 24 prominent large-scale research efforts in VCID.
- Identification of common goals and methodologies across these collaborative projects.
- Highlighting the establishment of consensus groups for harmonization and standardization.
Main Results:
- A comprehensive list of 24 significant national and international VCID research efforts is presented.
- These collaborations cover diverse aspects of VCID, from basic mechanisms to clinical treatment and prevention.
- Global harmonization of approaches, standardized terminology, and data sharing are becoming standard practices.
Conclusions:
- VCID research is increasingly becoming a global, collaborative endeavor.
- The highlighted large-scale efforts are poised to accelerate advancements in understanding and managing VCID.
- International collaboration is crucial for addressing the significant public health challenge posed by VCID.
Abstract:
Cerebrovascular disease is the second most common cause of cognitive disorders, usually referred to as vascular contributions to cognitive impairment and dementia (VCID) and makes some contribution to about 70 % of all dementias. Despite its importance, research into VCID has lagged as compared to cognitive impairment due to Alzheimer's disease. There is an increasing appreciation that closing this gap requires large national and international collaborations. This paper highlights 24 notable large-scale national and international efforts to advance research into VCID (MarkVCID, DiverseVCID, DISCOVERY, COMPASS-ND, HBC, RHU SHIVA, UK DRI Vascular Theme, STROKOG, Meta VCI Map, ISGC, ENIGMA-Stroke Recovery, CHARGE, SVDs@target, BRIDGET, CADASIL Consortium, CADREA, AusCADASIL, DPUK, DPAU, STRIVE, HARNESS, FINESSE, VICCCS, VCD-CRE Delphi). These collaborations aim to investigate the effects on cognition from cerebrovascular disease or impaired cerebral blood flow, the mechanisms of action, means of prevention and avenues for treatment. Consensus groups have been developed to harmonise global approaches to VCID, standardise terminology and inform management and treatment, and data sharing is becoming the norm. VCID research is increasingly a global collaborative enterprise which bodes well for rapid advances in this field.
