Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

[Prevention and therapy with immunoglobulin SRK].

M Schnoz, D H Ryser, S Barandun

    Helvetica Chirurgica Acta
    |May 1, 1979
    PubMed
    Summary

    This study shows that intravenous gamma-globulin (Ig) therapy is safe and effective for patients with primary humoral immunodeficiency, significantly reducing bacterial infections. Encouraging results were also seen in patients with severe septic-toxic infections.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Intervention for Cognitive Reserve Enhancement in Delaying the Onset of Alzheimer's Symptomatic Expression (INCREASE) Study: Results from a Randomized Controlled Study of Medication Therapy Management Targeting a Delay in Prodromal Dementia Symptom Progression.

    The journal of prevention of Alzheimer's disease·2022
    Same author

    Therapy for Clostridium difficile infection - any news beyond Metronidazole and Vancomycin?

    Expert review of clinical pharmacology·2017
    Same author

    Nitroimidazole carboxamides as antiparasitic agents targeting Giardia lamblia, Entamoeba histolytica and Trichomonas vaginalis.

    European journal of medicinal chemistry·2016
    Same author

    Martin F. Kagnoff, MD: 1941-2014.

    Mucosal immunology·2015
    Same author

    Validated gene expression biomarker analysis for biopsy-based clinical trials in ulcerative colitis.

    Alimentary pharmacology & therapeutics·2014
    Same author

    Protection against colitis by CD100-dependent modulation of intraepithelial γδ T lymphocyte function.

    Mucosal immunology·2013

    Area of Science:

    • Immunology
    • Clinical Medicine
    • Pharmacology

    Context:

    • Intravenous gamma-globulin (Ig) preparations are crucial for treating immunodeficiencies.
    • The "Zentrallaboratorium des Blutspendedienstes SRK" developed a novel pH 4-treated gamma-globulin.
    • Understanding the safety and efficacy of new therapeutic preparations is essential.

    Purpose:

    • To evaluate the tolerance and efficacy of a novel pH 4-treated gamma-globulin preparation for intravenous administration.
    • To assess the clinical outcomes in patients with primary humoral immunodeficiency receiving high-dose therapy.
    • To explore the potential of this gamma-globulin preparation in managing severe septic-toxic infections.

    Summary:

    • A clinical study demonstrated that intravenous gamma-globulin (Ig) therapy, prepared at pH 4, is well-tolerated and safe, even at high weekly doses (up to 99g).
    • In 15 patients with primary humoral immunodeficiency, this Ig preparation significantly reduced the frequency and severity of acute bacterial infections.
    • Results in 16 patients with severe septic-toxic infections, despite lacking antibody deficiency, were encouraging, suggesting broader therapeutic potential.

    Impact:

    • Establishes the safety and efficacy of a new gamma-globulin preparation for intravenous use.
    • Provides evidence for the successful treatment of primary humoral immunodeficiency, reducing infection rates.
    • Highlights promising outcomes for severe septic-toxic infections, warranting further clinical investigation.

    Related Experiment Videos