Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Aging01:26

Aging

52
Aging is a complex biological phenomenon influenced by various processes that affect cellular and systemic functions. Several prominent theories attempt to explain its mechanisms, highlighting cellular limitations, oxidative damage, and hormonal changes as central factors in aging.
Cellular Clock Theory
The cellular clock theory posits that the human lifespan is closely tied to the finite capacity of cells to divide, a phenomenon governed by telomeres, which are protective caps at the ends of...
52
Circadian Rhythms and Gene Regulation02:19

Circadian Rhythms and Gene Regulation

4.1K
The biological clock is involved in many aspects of regulating complex physiology in all animals. It was in 1935 when German zoologists, Hans Kalmus and Erwin Bünning, discovered the existence of circadian rhythm in Drosophila melanogaster. However, the internal molecular mechanisms behind the circadian clock remained a mystery until 1984, when Jeffrey C. Hall, Michael Rosbash, and Michael W. Young discovered the expression of the Per gene oscillating over a 24-hour cycle. In subsequent...
4.1K
Diencephalon: Anatomical Regions01:30

Diencephalon: Anatomical Regions

2.0K
The diencephalon, etymologically translated as 'through brain,' plays an integral role as the conduit between the cerebrum and the vast extent of the nervous system. However, the olfactory system is an exception, as it interfaces directly with the cerebrum. The diencephalon, deeply ensconced beneath the cerebrum, primarily consists of three paired structures — the thalamus, hypothalamus, and epithelamus. It also includes accessory structures such as the subthalamus, which houses the...
2.0K
Diencephalon: Hypothalamus and Coordination01:23

Diencephalon: Hypothalamus and Coordination

1.5K
The hypothalamus is a small yet highly complex and essential brain region that plays a crucial role in regulating various bodily functions. Anatomically, it is located at the base of the brain, just above the brainstem and below the thalamus, forming part of the limbic system.
The hypothalamus interacts with other brain regions, including the pituitary gland, through a direct physical connection called the hypothalamic-pituitary axis. The hypothalamus receives somatic and visceral inputs and...
1.5K
Understanding Sleep01:11

Understanding Sleep

229
Sleep, an essential biological state, involves significant reductions in physical activity, sensory awareness, and interaction with the environment. This complex physiological process is primarily regulated by specific brain regions, notably the hypothalamus and pons, which govern the sleep-wake cycle or circadian rhythm.
The circadian rhythm, a nearly 24-hour cycle, is deeply influenced by environmental light cues. Light exposure directly affects the hypothalamus, which in turn regulates...
229
The Pineal Gland01:02

The Pineal Gland

1.8K
The pineal gland, a diminutive endocrine structure named for its pinecone-shaped appearance, is situated atop the third ventricle within the diencephalon region of the forebrain. This gland, composed of secretory cells known as pinealocytes arranged in compact cords and clusters around dense particles of calcium salts, plays a pivotal role in hormonal regulation.
The primary secretion of the pineal gland is the hormone melatonin, derived from serotonin. The concentration of melatonin in the...
1.8K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Three-dimensional peptide modeling and subcellular localization of the VPg protein of human astrovirus 8 in infected Caco-2 cells.

Molecular biology reports·2026
Same author

<i>Mycobacterium tuberculosis</i> Infects Human Visceral White Adipocytes and Expresses Dormancy Genes and Inflammatory Cytokines: The Role of Visceral Adipocytes in Latent Tuberculosis Infection.

International journal of molecular sciences·2025
Same author

Publisher Correction: Transcriptional dynamics in type 2 diabetes progression is linked with circadian, thermogenic, and cellular stress in human adipose tissue.

Communications biology·2025
Same author

Transcriptional dynamics in type 2 diabetes progression is linked with circadian, thermogenic, and cellular stress in human adipose tissue.

Communications biology·2025
Same author

Transitions in chromatin conformation shaped by fatty acids and the circadian clock underlie hepatic transcriptional reorganization in obese mice.

Cellular and molecular life sciences : CMLS·2024
Same author

Time-of-day defines NAD<sup>+</sup> efficacy to treat diet-induced metabolic disease by synchronizing the hepatic clock in mice.

Nature communications·2023

Related Experiment Video

Updated: Jul 5, 2025

Parallel Measurement of Circadian Clock Gene Expression and Hormone Secretion in Human Primary Cell Cultures
06:53

Parallel Measurement of Circadian Clock Gene Expression and Hormone Secretion in Human Primary Cell Cultures

Published on: November 11, 2016

8.3K

Hypothalamic circuits and aging: keeping the circadian clock updated.

Rosa Vázquez-Lizarraga1, Lucia Mendoza-Viveros1,2,3, Carolina Cid-Castro1,2,3

  • 1Instituto Nacional de Medicina Genómica (INMEGEN), México City, México.

Neural Regeneration Research
|January 16, 2024
PubMed
Summary

The circadian clock is vital for healthy aging, coordinating cellular processes disrupted by aging. Enhancing brain and circadian function may offer systemic benefits for age-related diseases.

More Related Videos

In Vitro Bioluminescence Assay to Characterize Circadian Rhythm in Mammary Epithelial Cells
11:56

In Vitro Bioluminescence Assay to Characterize Circadian Rhythm in Mammary Epithelial Cells

Published on: September 28, 2017

9.8K
Monitoring Cell-autonomous Circadian Clock Rhythms of Gene Expression Using Luciferase Bioluminescence Reporters
10:38

Monitoring Cell-autonomous Circadian Clock Rhythms of Gene Expression Using Luciferase Bioluminescence Reporters

Published on: September 27, 2012

22.4K

Related Experiment Videos

Last Updated: Jul 5, 2025

Parallel Measurement of Circadian Clock Gene Expression and Hormone Secretion in Human Primary Cell Cultures
06:53

Parallel Measurement of Circadian Clock Gene Expression and Hormone Secretion in Human Primary Cell Cultures

Published on: November 11, 2016

8.3K
In Vitro Bioluminescence Assay to Characterize Circadian Rhythm in Mammary Epithelial Cells
11:56

In Vitro Bioluminescence Assay to Characterize Circadian Rhythm in Mammary Epithelial Cells

Published on: September 28, 2017

9.8K
Monitoring Cell-autonomous Circadian Clock Rhythms of Gene Expression Using Luciferase Bioluminescence Reporters
10:38

Monitoring Cell-autonomous Circadian Clock Rhythms of Gene Expression Using Luciferase Bioluminescence Reporters

Published on: September 27, 2012

22.4K

Area of Science:

  • Gerontology
  • Molecular Biology
  • Neuroscience

Background:

  • Age-related diseases like cancer and diabetes have increased, impacting quality of life.
  • Aging disrupts cellular regulation (transcriptional, translational, post-translational) due to stress and circadian issues.
  • The circadian clock is crucial for homeostasis and healthy aging, coordinating cellular functions like stem-cell activity and stress response.

Purpose of the Study:

  • To highlight the role of the circadian clock in healthy aging.
  • To explore strategies for enhancing hypothalamic and circadian function for systemic benefits.
  • To investigate intranasal drug delivery for targeting brain regions like the hypothalamus.

Main Methods:

  • Review of studies on aged animal models.
  • Analysis of molecular regulatory levels affected by aging.
  • Examination of the role of hypothalamic circuits and circadian rhythms.

Main Results:

  • Aging leads to discoordination in cellular processes and circadian derangements.
  • The circadian clock is essential for maintaining physiological homeostasis during aging.
  • Disruption of these processes negatively impacts stem-cell function, stress response, and inter-tissue communication.

Conclusions:

  • Enhancing hypothalamic and circadian function offers systemic benefits for healthy aging.
  • Pharmacological and non-pharmacological approaches targeting these systems are promising.
  • Intranasal drug delivery provides a targeted approach to the brain, reducing systemic side effects for age-related conditions.