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Updated: Jul 5, 2025
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Investigating Intestinal Inflammation in DSS-induced Model of IBD
Published on: February 1, 2012
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An Inflammatory Bowel Diseases Integrated Resources Portal (IBDIRP)
Nie Kai1,2, Cai Qingsong, Ma Kejia1,2
1Department of Gastroenterology, The Third Xiangya Hospital of Central South University, Changsha Hunan 410000, China.
Database : the Journal of Biological Databases and Curation
|January 16, 2024
Summary
A new integrated portal (IBDIRP) centralizes extensive data for Inflammatory Bowel Disease (IBD) research. This resource aids scientists by consolidating information on genetics, transcriptomics, microbiota, and metabolomics for IBD.
Area of Science:
- Gastroenterology and Immunology
- Bioinformatics and Computational Biology
- Genetics and Genomics
Background:
- Inflammatory Bowel Disease (IBD), encompassing ulcerative colitis and Crohn's disease, is a chronic gastrointestinal condition affecting millions globally.
- The vast and complex data landscape of IBD research, including literature, omics data, and bioresources, presents challenges for researchers.
- A need exists for a centralized, integrated platform to efficiently access and utilize diverse IBD-related information.
Purpose of the Study:
- To develop and launch the IBD Integrated Resources Portal (IBDIRP), a comprehensive online platform for IBD research.
- To consolidate, curate, and present diverse IBD data types, including genetic, transcriptomic, microbial, and metabolomic information.
- To provide a valuable, user-friendly resource for global IBD researchers to enhance their understanding and investigation of the disease.
Main Methods:
- Systematic collection and manual curation of IBD-related data from multiple sources, including PubMed, Google, GMrepo, gutMega, gutMDisorder, and Single Cell Portal.
- Development of distinct sections within the portal for single-nucleotide polymorphisms (SNPs), genes, transcriptome, microbiota, metabolomics, and single-cell data.
- Integration of interactive data visualization tools for single-cell data and a curated list of significant IBD web resources.
Main Results:
- Cataloged over 320 unique risk SNPs and presented more than 289 IBD-related genes.
- Compiled 153 manually curated IBD transcriptomics datasets (12,388 samples) from the Gene Expression Omnibus.
- Integrated downloadable microbiota data (23,149 taxonomic records) and metabolomics data from 24 studies (2,896 participants).
Conclusions:
- The IBDIRP is the first integrated resource specifically designed for global IBD researchers.
- This portal significantly enhances accessibility to comprehensive IBD knowledge, facilitating a multidimensional understanding of the disease.
- IBDIRP aims to empower researchers by providing a unified platform for diverse IBD data, thereby accelerating research and discovery.
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