Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Anatomy of the Intestines01:23

Anatomy of the Intestines

72.0K
Although digestion of proteins, carbohydrates, and lipids may begin in the stomach, it is completed in the intestine. The absorption of nutrients, water, and electrolytes from food and drink also occurs in the intestine. The intestines can be divided into two structurally distinct organs—the small and large intestines.
Small Intestines
The small intestine is an ~7 meter-long tube with an inner diameter of just 2.5 cm. Since most nutrients are absorbed here, the inner lining of the...
72.0K
Mismatch Repair01:20

Mismatch Repair

4.9K
Organisms are capable of detecting and fixing nucleotide mismatches that occur during DNA replication. This sophisticated process requires identifying the new strand and replacing the erroneous bases with correct nucleotides. Mismatch repair is coordinated by many proteins in both prokaryotes and eukaryotes.
The Mutator Protein Family Plays a Key Role in DNA Mismatch Repair
The human genome has more than 3 billion base pairs of DNA per cell. Prior to cell division, that vast amount of genetic...
4.9K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

A Liposomal Nanovaccine Reprograms Post-Ablation Macrophages to Sustain Antitumor Immunity in Hepatocellular Carcinoma.

Acta biomaterialia·2026
Same author

Electrical stimulation as an emerging strategy in bone repair: Mechanisms, applications, and advances.

Journal of orthopaedic translation·2026
Same author

Metabolic Dysfunction-Associated Steatotic Liver Disease as a Systemic Driver of Heart Failure With Preserved Ejection Fraction: Mechanistic Insights and Emerging Therapeutic Perspectives.

Reviews in cardiovascular medicine·2026
Same author

Comments on "The effect of remimazolam versus propofol on respiratory depression for non‑intubated general anesthesia: a randomized controlled trial".

Journal of anesthesia·2026
Same author

Joint association of high-sensitivity C-reactive protein and cumulative atherogenic index of plasma with cardiovascular disease risk in CKM syndrome stages 0-3: a prospective cohort study.

BMC cardiovascular disorders·2026
Same author

Aligned core-sheath structured fibers prevent intimal hyperplasia via modulate macrophage polarization and smooth muscle cell phenotype in vascular regeneration.

Journal of nanobiotechnology·2026

Related Experiment Video

Updated: Jul 5, 2025

Murine Fecal Isolation and Microbiota Transplantation
07:32

Murine Fecal Isolation and Microbiota Transplantation

Published on: May 26, 2023

4.1K

Causal Relationship between Gut Microbiota and Aneurysm: A Mendelian Randomization Study.

Zhentao Tan1,2, Menghui Mao3, Zhe Jiang3

  • 1Jiaxing University Master Degree Cultivation Base, Zhejiang Chinese Medical University, Jiaxing, China, tanchanto@outlook.com.

Cerebrovascular Diseases (Basel, Switzerland)
|January 16, 2024
PubMed
Summary

This study establishes causal links between specific gut microbes and various aneurysms, paving the way for novel microbiome-based prevention strategies and biomarkers for aortic aneurysm and cerebral aneurysm.

Keywords:
AneurysmGut microbiotaMendelian randomization

More Related Videos

Microbiota Analysis Using Two-step PCR and Next-generation 16S rRNA Gene Sequencing
11:22

Microbiota Analysis Using Two-step PCR and Next-generation 16S rRNA Gene Sequencing

Published on: October 15, 2019

28.0K
An In Vitro Batch-culture Model to Estimate the Effects of Interventional Regimens on Human Fecal Microbiota
07:15

An In Vitro Batch-culture Model to Estimate the Effects of Interventional Regimens on Human Fecal Microbiota

Published on: July 31, 2019

9.6K

Related Experiment Videos

Last Updated: Jul 5, 2025

Murine Fecal Isolation and Microbiota Transplantation
07:32

Murine Fecal Isolation and Microbiota Transplantation

Published on: May 26, 2023

4.1K
Microbiota Analysis Using Two-step PCR and Next-generation 16S rRNA Gene Sequencing
11:22

Microbiota Analysis Using Two-step PCR and Next-generation 16S rRNA Gene Sequencing

Published on: October 15, 2019

28.0K
An In Vitro Batch-culture Model to Estimate the Effects of Interventional Regimens on Human Fecal Microbiota
07:15

An In Vitro Batch-culture Model to Estimate the Effects of Interventional Regimens on Human Fecal Microbiota

Published on: July 31, 2019

9.6K

Area of Science:

  • Microbiology
  • Genetics
  • Cardiovascular Research

Background:

  • Observational studies suggest a gut microbiota (GM) and aneurysm link, but causality is unclear due to limitations.
  • Reverse causation and confounding factors hinder understanding of the GM-aneurysm relationship.
  • This study addresses the knowledge gap by investigating a causal link between GM and aneurysm development.

Purpose of the Study:

  • To establish a causal relationship between gut microbiota composition and aneurysm development.
  • To identify specific microbial taxa associated with increased or decreased risk of various aneurysms.
  • To provide a foundation for developing microbiome-based interventions for aneurysm prevention.

Main Methods:

  • Utilized Mendelian randomization (MR) with summary statistics from genome-wide association studies.
  • Employed inverse-variance weighting as the primary MR technique for causal effect estimation.
  • Conducted sensitivity analyses using weighted median, MR-Egger, MR-PRESSO, and simple mode methods to ensure robustness and investigate bias.

Main Results:

  • Identified varying associations between specific microbial taxa and different aneurysms.
  • Observed negative correlations between aortic aneurysm (AA) and certain taxa (e.g., Lentisphaerae), and positive correlations with others (e.g., FamilyXIIIUCG001).
  • Found specific gut bacteria linked to reduced or increased risk for abdominal AA, thoracic AA, and cerebral aneurysm (CA).

Conclusions:

  • Established causal relationships between specific gut microbiota components and various aneurysm types.
  • Findings may facilitate the development of microbiome-based interventions for aneurysm prevention.
  • Identified potential novel biomarkers for targeted aneurysm prevention strategies.