Related Experiment Video
Updated: Jul 5, 2025
10:03
Bioengineering of Humanized Bone Marrow Microenvironments in Mouse and Their Visualization by Live Imaging
Published on: August 1, 2017
11.7K
Hematopoietic Stem Cells and Their Bone Marrow Niches
1Department of Pharmacology & Regenerative Medicine, College of Medicine, University of Illinois at Chicago, Chicago, IL, USA. spinho@uic.edu.
Advances in Experimental Medicine and Biology
|January 16, 2024
Summary
Hematopoietic stem cells (HSCs) reside in the bone marrow niche, which controls their functions. This chapter explores HSC niche research history, HSC-niche interactions, and HSC heterogeneity within the niche.
Area of Science:
- Hematology
- Stem Cell Biology
- Microenvironment Research
Background:
- Hematopoietic stem cells (HSCs) are crucial for blood formation and are regulated by their bone marrow microenvironment, termed the niche.
- Understanding the HSC niche is vital for comprehending stem cell regulation, aging, and diseases.
Purpose of the Study:
- To provide a historical overview of hematopoietic stem cell niche research.
- To review the complex interdependencies between HSCs and their niche.
- To highlight recent advancements in understanding HSC heterogeneity and niche interactions.
Main Methods:
- Literature review and synthesis of existing research on HSC niche biology.
- Analysis of studies focusing on HSC subpopulations and their microenvironmental interactions.
- Integration of historical perspectives with current findings in the field.
Main Results:
- The bone marrow niche plays a critical role in regulating HSC proliferation, self-renewal, and differentiation.
- Recent research reveals significant heterogeneity among HSC subpopulations.
- Specific cellular and molecular constituents within the niche interact dynamically with HSCs.
Conclusions:
- The HSC niche is a dynamic regulatory system essential for maintaining blood homeostasis.
- Further investigation into HSC heterogeneity and niche interactions promises new therapeutic strategies.
- A comprehensive understanding of the HSC niche is fundamental for advancing stem cell biology and regenerative medicine.
More Related Videos
11:06Combining Intravital Fluorescent Microscopy IVFM with Genetic Models to Study Engraftment Dynamics of Hematopoietic Cells to Bone Marrow Niches
Published on: March 21, 2017
8.0K
08:34Flow Cytometry Analysis of Murine Bone Marrow Hematopoietic Stem and Progenitor Cells and Stromal Niche Cells
Published on: September 28, 2022
4.2K
Related Concept Videos
01:26Stem Cell Niche
5.1K
The stem cell niche is the dynamic microenvironment where stem cells reside. Inside these niches, the cells may remain undifferentiated, undergo high self-renewal, or become lineage-specific progenitors. Stem cells coexist with other niche cells, such as stromal cells. They also interact closely with the ECM. Cell-cell and cell-matrix communication occur via adhesion molecules or soluble factors that signal the stem cells and determine their fate. Stromal cells also provide survival signals to...
5.1K
01:19Multipotency of Hematopoietic Stem Cells
3.1K
The hematopoietic stem cells or HSCs are multipotent, meaning they can differentiate and give rise to all blood and immune cells. HSCs are maintained in the quiescent stage until an external stimulus initiates their differentiation. The multipotent HSCs exist as two heterogeneous populations, long-term repopulating cells (LTRC) and short-term repopulating cells (STRC). The two HSC populations have different surface markers or receptors and are classified based on quiescence and long-term...
3.1K
01:21Hematopoiesis
5.3K
The process of blood cell formation is called hematopoiesis. Hematopoiesis starts early during development, on the seventh day of embryogenesis. This phase of hematopoiesis is called the primitive wave, wherein the extraembryonic yolk sac allows the production of erythroid cells and endothelial cells from a common precursor called hemangioblast. The erythroid cells provide oxygen to support the growth of the rapidly dividing embryo. Hemangioblasts later develop into hematopoietic stem cells or...
5.3K
01:20Overview of Hematopoiesis
4.0K
Hematopoiesis, or blood cell production, is a vital biological process that begins early in embryonic development and continues throughout life. This process generates the various types of cells found in blood, including red blood cells, white blood cells, and platelets from hematopoietic stem cells (HSCs).
Developmental Phases of Hematopoiesis
Initially, HSCs are formed in the embryonic yolk sac, a critical site for early blood cell production. These stem cells subsequently migrate to other...
Developmental Phases of Hematopoiesis
Initially, HSCs are formed in the embryonic yolk sac, a critical site for early blood cell production. These stem cells subsequently migrate to other...
4.0K
01:01Regulation of Hematopoietic Stem Cells
3.2K
All blood and immune cells are produced from the multipotent hematopoietic stem cells (HSCs) by the process of hematopoiesis. However, they all have a limited life span. In addition, many are depleted in immune surveillance or combatting an injury or infection. This makes blood one of the most regenerative tissues. Hematopoiesis helps replenish these blood and immune cells, restoring the body's normal functioning. However, overproduction of blood and immune cells can make them cancerous or...
3.2K
01:34Production of Formed Elements
1.4K
Hemangioblasts are multipotent stem cells originating from the mesoderm. They give rise to hematopoietic stem cells (HSCs), which undergo hematopoiesis to produce all the formed elements of blood. This process is regulated by a complex network of hematopoietic growth factors, including transcription factors, growth factors, and cytokines. These factors stimulate the HSCs to divide and differentiate, though some HSCs remain undifferentiated to maintain a self-renewing pool.
Most HSCs commit to...
Most HSCs commit to...
1.4K