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Updated: Jul 5, 2025

Directed Differentiation of Primitive and Definitive Hematopoietic Progenitors from Human Pluripotent Stem Cells
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Directed Differentiation of Primitive and Definitive Hematopoietic Progenitors from Human Pluripotent Stem Cells

Published on: November 1, 2017

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Multi-lineage Differentiation from Hematopoietic Stem Cells

Xiaoshuang Wang1,2, Siqi Liu3, Jia Yu4,5

  • 1The State Key Laboratory for Complex, Severe, and Rare Diseases, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences / Peking Union Medical College, Beijing, China. wangxs@ibms.pumc.edu.cn.

Advances in Experimental Medicine and Biology
|January 16, 2024
PubMed

The hematopoietic stem cells (HSCs) have the ability to differentiate and give rise to all mature blood cells. Commitment to differentiation progressively limits the self-renewal potential of the original HSCs by regulating the level of lineage-specific gene expression. In this review, we will summarize the current understanding of the molecular mechanisms underlying HSC differentiation toward erythroid, myeloid, and lymphocyte lineages. Moreover, we will decipher how the single-cell technologies advance the lineage-biased HSC subpopulations and their differentiation potential.

Keywords:
Epigenetic regulationHematopoietic stem cellLineage differentiationNon-coding RNASingle-cell technologyTranscription factor networks

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