Factors influencing DVT formation in sepsis

Area of Science:

• Cardiovascular Disease
• Critical Care Medicine
• Hematology

Background:

• Sepsis presents a significant global health challenge.
• Deep vein thrombosis (DVT) is a major cause of cardiovascular mortality.
• Understanding DVT risk factors in sepsis is crucial for patient outcomes.

Purpose of the Study:

• To investigate factors associated with DVT development in sepsis patients.
• To identify clinical and laboratory predictors of DVT in this population.
• To analyze the impact of DVT on sepsis patient prognosis.

Main Methods:

• A survey of 918 sepsis patients undergoing DVT screening at Peking Union Medical College Hospital.
• Data collection spanned from June 2013 to October 2022.
• Analysis included demographics, comorbidities, inflammatory markers, albumin, SOFA scores, coagulation, and organ function.

Main Results:

• DVT prevalence in sepsis patients was 23%.
• Elderly patients, and those with hypertension or atrial fibrillation showed higher DVT rates.
• Serum albumin levels correlated with DVT; poorer liver function and better coagulation/respiration were associated with DVT.
• DVT patients experienced longer mechanical ventilation and ICU stays, but survival rates were similar.

Conclusions:

• Sepsis-associated DVT is influenced by age, comorbidities, and organ function.
• While inflammatory markers and SOFA scores were not significant predictors, coagulation, respiration, and liver function play key roles.
• DVT in sepsis is linked to prolonged critical care and hospitalization, underscoring the need for targeted prevention strategies.