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The Goeckerman Regimen for the Treatment of Moderate to Severe Psoriasis
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A Practical Guide to Using Biologics in Pediatric Dermatology

Annie George1, Rafael Paolo Lansang2, Perla Lansang1,3

  • 1Temerty School of Medicine, University of Toronto, Toronto, ON, Canada.

Journal of Cutaneous Medicine and Surgery
|January 17, 2024
PubMed

Insights

Biologic therapies are safe and effective for treating pediatric inflammatory skin diseases like psoriasis, hidradenitis suppurativa (HS), atopic dermatitis (AD), and chronic spontaneous urticaria (CSU). This guide provides a framework for their use in children.

Area of Science:

  • Pediatric Dermatology
  • Immunology
  • Inflammatory Diseases

Background:

  • Psoriasis, HS, AD, and CSU are common chronic inflammatory skin conditions in children.
  • Biologics are increasingly used, but provider concerns about pediatric safety and efficacy persist.

Purpose of the Study:

  • To provide a practical guide for initiating biologic therapy in pediatric patients with psoriasis, HS, AD, and CSU.
  • To establish a methodological framework focusing on baseline work-up, monitoring, and dosing.

Main Methods:

  • Review of emerging evidence on biologic safety and efficacy in pediatric populations.
  • Development of a framework for clinical management, including specific considerations for children.

Main Results:

  • Emerging evidence supports the safety and efficacy of biologic therapies in pediatric patients.
  • A structured approach to initiating and monitoring biologics can address provider concerns.

Conclusions:

  • Biologic therapy is a viable and safe treatment option for pediatric inflammatory skin diseases.
  • A standardized framework is crucial for optimizing biologic use and addressing safety concerns in children.

Keywords:
atopic dermatitisbiologicschronic spontaneous urticariahidradenitis suppurativapediatricspsoriasis

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