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Establishment of Rat Models Mimicking Gender-affirming Hormone Therapies

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Testosterone replacement therapy: clinical considerations.

Patrick M Luther¹, Noah J Spillers¹, Norris C Talbot¹

¹School of Medicine, Louisiana State University Health Sciences Center Shreveport, Shreveport, LA, USA.

Expert Opinion on Pharmacotherapy

|January 17, 2024

Summary

This summary is machine-generated.

Testosterone replacement therapy (TRT) offers benefits like improved libido and muscle mass for hypogonadism. Recent studies indicate benefits outweigh risks, but further research is needed for age-related hypogonadism.

Keywords:

TRT Testosterone hypogonadism prostate testosterone replacement therapy

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Area of Science:

Endocrinology
Men's Health
Pharmacology

Background:

Testosterone replacement therapy (TRT) is a popular treatment for hypogonadism.
TRT offers benefits including improved libido, muscle mass, cognition, and quality of life.
Potential side effects include polycythemia, prostate issues, gynecomastia, and infertility.

Conclusions:

TRT can significantly improve quality of life and alleviate hypogonadism symptoms.
Careful consideration of potential side effects and co-therapies is essential.
Further well-designed clinical trials are recommended for symptomatic age-related hypogonadism.