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Updated: Jul 5, 2025

Targeted Next-generation Sequencing and Bioinformatics Pipeline to Evaluate Genetic Determinants of Constitutional Disease
Published on: April 4, 2018
Multi-dichotomous sequencing method MDSM for ordering the importance of variants' properties in multi-criteria
Hubert Anysz1, Bartosz Grucza2
1Warsaw University of Technolgy, Faculty of Civil Engineering, Al. Armii Ludowej 16, Warsaw 00-637, Poland.
Abstract:
There are plenty of Multi-Criteria Decision-Making (MCDM) methods that help to choose the most suitable solution assessed by several criteria (e.g. Saaty 1990; Simos 1990; Pamučar et al. 2018). They are applied in cases where several scales of different units describe the variants or the variants' properties are represented by linguistic, non-numbered terms. The inherent part of the MCDM algorithms is calculating the weights of the variants' properties, necessary for ordering the variants. If - in a certain problem - there are several properties to consider, sequencing their importance becomes a problem itself. The innovative method of sequencing is proposed in the article based on dichotomous splitting of the properties' importance. If made several times, it leads to the coherent - internally and with the decision-maker's intention - order of the properties' importance. Then the weights of the properties can be calculated with the use of different MCDM methods. The description of the method can be shortened as follows:•Divide the full set of features into two dichotomous subsets of lower and higher importance•Continue dichotomous divisions until there are only the subsets containing one element or subsets containing elements of equal importance.
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