[Evaluation of the metabolizing function of the liver in thyrotoxicosis using the antipyrine test]

A study was made of pharmacometabolizing liver function in 73 patients with thyrotoxicosis of various degree and duration. The antipyrine test was used to assess pharmacometabolizing liver function. In thyrotoxicosis of moderate severity and in severe forms with the period of the disease over 1 year the half-life increased and antipyrine clearance decreased. Experimental and clinical studies confirmed that a course of therapy with antithyroid drugs promoted the normalization of disturbed pharmacometabolizing liver function.