Related Experiment Video

Updated: Jul 5, 2025

Isolation of Human Islets from Partially Pancreatectomized Patients
11:10

Isolation of Human Islets from Partially Pancreatectomized Patients

Published on: July 30, 2011

16.3K

Lack of Association of A1C With Postoperative Complications in Children With Type 1 or Type 2 Diabetes

Grace Kim1, McKenna C Richards2, Abigail B Smith2

  • 1Department of Pediatrics, Division of Diabetes and Endocrinology, Baylor College of Medicine, Texas Children's Hospital, Houston, TX.

Clinical Diabetes : a Publication of the American Diabetes Association
|January 17, 2024
PubMed

Insights

Elevated preoperative A1C levels were not associated with increased postoperative complications in children with diabetes undergoing elective surgery. This suggests that delaying elective procedures for glycemic optimization is unnecessary in pediatric patients with diabetes.

Area of Science:

  • Pediatric Endocrinology
  • Surgical Outcomes
  • Diabetes Management

Background:

  • Adult studies suggest a link between high A1C and postoperative complications.
  • Limited research exists on this association in pediatric populations with diabetes.
  • Type 1 and type 2 diabetes are common in children requiring surgical intervention.

Purpose of the Study:

  • To investigate the relationship between preoperative A1C levels and postoperative complications in children with diabetes.
  • To determine if elevated A1C predicts adverse outcomes after elective noncardiac surgery or diagnostic procedures in pediatric patients.
  • To inform clinical guidelines regarding surgical timing in diabetic children.

Main Methods:

  • Retrospective chart review of pediatric patients with type 1 or type 2 diabetes.
  • Inclusion criteria: elective noncardiac surgery or diagnostic procedures.
  • Data collection on preoperative A1C levels and postoperative complication incidence.

Main Results:

  • No statistically significant association was found between elevated preoperative A1C levels and the incidence of postoperative complications.
  • Specific complication rates did not correlate with higher glycemic control indicators.
  • The findings were consistent across different types of elective procedures.

Conclusions:

  • Preoperative A1C levels do not appear to be a significant predictor of postoperative complications in children with diabetes.
  • Elective noncardiac surgery or diagnostic procedures in children with diabetes can proceed without mandatory A1C optimization.
  • Current evidence does not support delaying elective surgery solely based on preoperative A1C levels in this pediatric cohort.

More Related Videos

Glycemic Impact on Knee Osteoarthritis Symptoms on Physical, Radiographic, and Inflammatory Markers among Individuals Aged 50 and Over with Diabetes07:22

Glycemic Impact on Knee Osteoarthritis Symptoms on Physical, Radiographic, and Inflammatory Markers among Individuals Aged 50 and Over with Diabetes

Published on: March 7, 2025

230
A Protocol for Constructing a Rat Wound Model of Type 1 Diabetes05:18

A Protocol for Constructing a Rat Wound Model of Type 1 Diabetes

Published on: February 17, 2023

3.9K

Related Concept Videos

Diabetes Mellitus: Type 2 and Gestational01:22

Diabetes Mellitus: Type 2 and Gestational

Type 2 diabetes, characterized by insulin resistance, arises when the insulin receptors on cells lose responsiveness to insulin, diminishing the cell's capacity to take up glucose, resulting in elevated blood glucose levels. To receive a diagnosis of Type 2 diabetes, a series of blood glucose tests are necessary to assess whether the blood glucose falls within normal parameters. If the result is out of the normal range, a patient may be diagnosed as prediabetic or diabetic, depending on the...
2.4K
Diabetes: Symptoms, Diagnosis, and Complications01:15

Diabetes: Symptoms, Diagnosis, and Complications

For most patients, experiencing several weeks of polyuria, polydipsia, fatigue, and significant weight loss may indicate the presence of diabetes. Furthermore, adults displaying the phenotypic appearance of type 2 diabetes (particularly those who are obese and not initially insulin-requiring), may have islet cell autoantibodies, suggesting autoimmune-mediated β cell destruction and a diagnosis of latent autoimmune diabetes of adults (LADA). The categorization of glucose homeostasis is...
546
Diabetes Mellitus: Overview and Type I Subtype01:22

Diabetes Mellitus: Overview and Type I Subtype

Diabetes mellitus is a chronic metabolic disorder characterized by high blood glucose levels due to inadequate insulin production, insulin resistance, or both. The condition affects millions worldwide and can significantly impact their health and quality of life.
Type 1 diabetes is an autoimmune disease in which the immune system mistakenly attacks and destroys the insulin-producing beta cells in the pancreas. As a result, the body is unable to produce sufficient insulin, and individuals with...
2.6K
Pathophysiology of Diabetes01:20

Pathophysiology of Diabetes

Diabetes mellitus is a chronic metabolic disorder characterized by hyperglycemia. The four categories of diabetes are type 1 diabetes, type 2 diabetes, other specific types of diabetes, and gestational diabetes.
Type 1 diabetes is characterized by autoimmune-mediated destruction of pancreatic β cells, with environmental factors potentially triggering this process in genetically susceptible individuals. Despite many not having a family history, certain genes increase susceptibility,...
940
Carbohydrate Metabolism01:36

Carbohydrate Metabolism

Carbohydrates are polymers composed of molecules containing atoms of carbon, hydrogen and oxygen. One gram of carbohydrate can provide four kilo-calories of energy, which makes it the most efficient instant energy source.
Starch accounts for approximately 60% of the carbohydrates consumed by humans. Since amylase enzymes cannot function in the stomach's acidic environment, starch can only be digested in the mouth and small intestine. Simple sugars are found naturally in milk and fruits in...
11.1K
Insulin: Dosing Regimen and Adverse Effects01:16

Insulin: Dosing Regimen and Adverse Effects

Insulin-replacement therapy usually includes both long-acting insulin (basal) and short-acting insulin (to cater to postprandial needs). In a diverse group of type 1 diabetes patients, the average daily insulin dose is typically 0.5-0.7 units/kg body weight. However, obese patients and pubertal adolescents may need more due to insulin resistance.
The basal dose constitutes about 40%-50% of the total daily dose, with the rest as premeal insulin. The mealtime insulin dose should mirror...
175