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Updated: Jul 5, 2025

Isolation of Whole Cell Protein Lysates from Mouse Facial Processes and Cultured Palatal Mesenchyme Cells for Phosphoprotein Analysis
Published on: April 1, 2022
X-linked hypophosphatemia, fibroblast growth factor 23 signaling, and craniosynostosis
Chelsey Grimbly1,2, Daniel Graf2,3, Leanne M Ward4
1Department of Pediatrics, Edmonton Clinic Health Academy, University of Alberta, Edmonton, AB T6G 2R7, Canada.
Abstract:
This review summarizes the current knowledge of fibroblast growth factor 23 signaling in bone and its role in the disease pathology of X-linked hypophosphatemia. Craniosynostosis is an under-recognized complication of X-linked hypophosphatemia. The clinical implications and potential cellular mechanisms invoked by increased fibroblast growth factor 23 signaling causing craniosynostosis are reviewed. Knowledge gaps are identified and provide direction for future clinical and basic science studies.
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