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Endothelial dysfunction and cardiovascular diseases: The role of human induced pluripotent stem cells and tissue

Mary H C Florido1,2,3, Nicholas P Ziats1,4

  • 1Department of Pathology, Case Western Reserve University, Cleveland, Ohio, USA.

Journal of Biomedical Materials Research. Part A
|January 17, 2024
PubMed

Insights

Novel therapies for cardiovascular disease (CVD) are crucial. Combining stem cell biology and bioengineering advances tissue engineering for CVD treatment, mimicking native tissues for better outcomes.

Area of Science:

  • Biomedical Engineering
  • Stem Cell Biology
  • Cardiovascular Research

Background:

  • Cardiovascular disease (CVD) is the leading global cause of mortality.
  • Understanding CVD pathophysiology is vital for developing new treatments.
  • Endothelial cell dysfunction plays a significant role in CVD.

Purpose of the Study:

  • To review advancements in cardiovascular disease research.
  • To highlight the synergy between stem cell biology and bioengineering.
  • To discuss the impact on cardiovascular tissue engineering and treatment.

Main Methods:

  • Review of recent studies on CVD, endothelial cells, and dysfunction.
  • Exploration of stem cell biology techniques, including reprogramming human pluripotent stem cells.
  • Discussion of bioengineering approaches using organic and inorganic biomaterials to mimic extracellular matrix.

Main Results:

  • Stem cell technology enables generation of various cell types.
  • Biomaterials facilitate in vitro recapitulation of organ structures.
  • The integration of stem cell biology and bioengineering accelerates progress in CVD research.

Conclusions:

  • The convergence of stem cell biology and bioengineering offers significant promise for cardiovascular disease treatment.
  • Tissue engineering strategies are advancing cardiovascular device development.
  • Further research in this interdisciplinary field is essential for novel therapeutic interventions.

Keywords:
cardiovascular diseaseendotheliumstem cellstissue engineering

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