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Tibolone and Breast Cancer

Jae Kyung Lee1,2, Hyewon Yun1,2, Heeyon Kim1,2

  • 1Departments of Obstetrics and Gynecology, Yonsei University College of Medicine, Seoul, Korea.

Journal of Menopausal Medicine
|January 17, 2024
PubMed

Insights

Tibolone, a selective estrogenic activity regulator, shows no increased breast cancer risk. This review focuses on recent studies, especially in Asian populations, regarding tibolone and breast health.

Area of Science:

  • Endocrinology
  • Oncology
  • Pharmacology

Background:

  • Tibolone is a synthetic steroid selective estrogenic activity regulator.
  • Unlike conventional therapies, tibolone has tissue-specific effects, activating estrogenic activity in the brain, vagina, and bone.
  • Tibolone is inactive in the endometrium and breast, prompting investigation into its breast cancer risk.

Purpose of the Study:

  • To determine the effects of tibolone on breast tissue.
  • To investigate the relationship between tibolone use and breast cancer risk.
  • To focus on recent studies, particularly those involving Asian populations.

Main Methods:

  • Review of recent scientific literature.
  • Analysis of studies investigating tibolone's impact on breast health.
  • Emphasis on epidemiological data from Asian populations.

Main Results:

  • Tibolone does not appear to increase the risk of breast cancer.
  • Estrogenic activity is localized, sparing breast tissue.
  • Recent research, including Asian studies, supports a neutral or potentially protective effect.

Conclusions:

  • Tibolone is a safe menopausal hormone therapy option regarding breast cancer risk.
  • Selective tissue estrogenic activity regulation offers benefits without typical risks.
  • Further research in diverse populations is warranted but current evidence is reassuring.
Keywords:
Breast densityBreast neoplasmsPostmenopausal hormone replacement therapyTibolone

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