Patient-targeted education (ePRO-E) to increase ePRO intent within an Alliance clinical trial (A221805-SI1)

Area of Science:

• Oncology
• Clinical Trials
• Health Informatics

Background:

• The National Cancer Institute National Clinical Trials Network (NCTN) adopted the Patient Cloud ePRO app for electronic patient-reported outcome (ePRO) data collection.
• Low utilization of the ePRO app within the NCTN has been observed, necessitating strategies to improve adoption and data quality.

Purpose of the Study:

• To evaluate the effectiveness of a patient-targeted ePRO educational resource (ePRO-E) in increasing ePRO intent and improving data quality within an NCTN study.
• To assess the impact of technology attitudes on ePRO selection.

Main Methods:

• A prospective study compared an intervention group exposed to the ePRO-E (written materials and video) with a historical control group.
• ePRO intent and data quality (≥80% survey submission) were primary outcomes, with covariates including technology attitudes, demographics, and comorbidity.
• A total of 69 participants were included in the comparison.

Main Results:

• The intervention group showed significantly higher ePRO intent (78.8%) compared to the historical control group (47.1%).
• Patients with higher technology attitudes were more likely to choose ePRO surveys.
• Despite increased intent, the ePRO group had a significantly lower data submission rate (30.6%) compared to the paper survey group (57.9%).

Conclusions:

• The ePRO-E intervention successfully increased patient intent to use electronic patient-reported outcomes.
• Positive technology attitudes are associated with higher ePRO adoption.
• Additional strategies are required to enhance the quality and completeness of ePRO data submission in clinical trials.