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Updated: Jul 5, 2025

The Multiple Sclerosis Performance Test MSPT: An iPad-Based Disability Assessment Tool
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An update on managing patients with multiple sclerosis in primary care

Paula Hardeman1

  • 1Paula Hardeman is lead advanced practice provider in the ambulatory clinic of the Department of Neurology at UT Southwestern Medical Center in Dallas, Tex. The author has disclosed no potential conflicts of interest, financial or otherwise.

JAAPA : Official Journal of the American Academy of Physician Assistants
|January 17, 2024
PubMed

Insights

Multiple sclerosis (MS) is an inflammatory central nervous system disease. Early treatment with immune-suppressing therapies can prevent relapses and disease progression, but requires careful risk-benefit assessment.

Area of Science:

  • Neurology
  • Immunology
  • Neuroimmunology

Background:

  • Multiple sclerosis (MS) is an immune-mediated inflammatory disease of the central nervous system.
  • It is a leading cause of disability in young adults.
  • Early intervention is crucial for managing relapses and slowing disease progression.

Purpose of the Study:

  • To review the evolving landscape of multiple sclerosis treatments.
  • To highlight the efficacy of newer immunosuppressant therapies.
  • To emphasize the importance of understanding associated risks and benefits.

Main Methods:

  • Literature review of immune-modulating and immunosuppressant therapies for MS.
  • Analysis of treatment efficacy in preventing relapses and progression.
  • Evaluation of safety profiles, including serious adverse reactions.

Main Results:

  • Early treatments for MS primarily modulated the immune system.
  • Newer immunosuppressant therapies demonstrate greater effectiveness in preventing relapses and progression.
  • These potent therapies are associated with significant risks and adverse reactions.

Conclusions:

  • Evidence-based early treatment is vital for managing multiple sclerosis.
  • The increased use of immunosuppressants necessitates a thorough understanding of their risks and benefits.
  • Informed clinical decision-making is essential for optimizing patient outcomes in MS.

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