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Updated: Jul 5, 2025
Coronary Progenitor Cells and Soluble Biomarkers in Cardiovascular Prognosis after Coronary Angioplasty
Published on: January 28, 2020
High-density lipoprotein-related inflammatory indices predict repeat revascularization in coronary drug-eluting
Xuantong Guo1, Ruihuan Shen2, Yanni Su1
1State Key Laboratory of Cardiovascular Disease, Department of Cardiology, National Clinical Research Center of Cardiovascular Diseases, National Center for Cardiovascular Diseases, Fuwai Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, 100037, China.
Insights
High-density lipoprotein cholesterol (HDL-C)-related inflammatory indices can predict repeat revascularization after stenting. These markers, including monocyte-to-HDL-C ratio, are valuable for assessing risk in patients undergoing coronary procedures.
Area of Science:
- Cardiology
- Inflammation Biomarkers
- Interventional Cardiology
Background:
- Repeat revascularization (RR) is a concern after coronary stenting.
- HDL-C-related inflammatory indices are being investigated as potential predictors of RR.
Purpose of the Study:
- To evaluate the predictive value of HDL-C-related inflammatory indices for RR after coronary drug-eluting stenting.
- To identify specific indices associated with increased RR risk.
Main Methods:
- Multivariable Cox regression analysis was employed.
- Restricted cubic splines and receiver operating curve analyses were utilized.
- Patient data with a median follow-up of 50 months were analyzed.
Main Results:
- 521 patients (35.42%) experienced RR.
- Higher monocyte-to-HDL-C, neutrophil-to-HDL-C, and lymphocyte-to-HDL-C ratios were associated with increased RR incidence.
- The largest tertiles of monocyte-to-HDL-C, neutrophil-to-HDL-C, white blood cell-to-HDL-C, and lymphocyte-to-HDL-C ratios increased RR risk by 38%, 30%, 28%, and 37%, respectively.
- Monocyte-to-HDL-C ratio showed a dose-responsive and linear correlation with RR.
- HDL-C-related inflammatory indices demonstrated over 60% predictive ability.
Conclusions:
- HDL-C-related inflammatory indices independently predict RR after coronary drug-eluting stenting.
- These indices serve as valuable biomarkers for risk stratification in post-stenting patients.
Abstract:
Background: HDL-C-related inflammatory indices are potential predictors of repeat revascularization (RR) after coronary drug-eluting stenting. Methods: Multivariable Cox regression with restricted cubic splines and receiver operating curve was used. Results: The median follow-up was 50 months. A total of 521 (35.42%) patients experienced RR. The incidence of RR was positively associated with the monocyte-to-HDL-C ratio, neutrophil-to-HDL-C ratio and lymphocyte-to-HDL-C ratio (log-rank p < 0.05). After being fully adjusted, the largest tertile of monocyte-to-HDL-C ratio, neutrophil-to-HDL-C ratio, white blood cell-to-HDL-C ratio and lymphocyte-to-HDL-C ratio increased the risk by 38, 30, 28 and 37%, respectively. Monocyte-to-HDL-C ratio was dose-responsive and linearly correlated with RR. HDL-C-related inflammatory indices had over 60% predictive ability. Conclusion: HDL-C-related inflammatory indices independently predicted RR after coronary drug-eluting stenting.
