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Related Concept Videos

Bone Remodeling01:40

Bone Remodeling

Bone remodeling is a continuous and balanced process of bone resorption by osteoclasts and bone formation by osteoblasts. In adults, it helps maintain bone mass and calcium homeostasis. While mechanical stress can stimulate turnover as part of the normal maintenance and reparative process, several hormones also regulate bone remodeling.

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Dextran-Based Injectable Hydrogel Composites for Bone Regeneration.

Patrícia Alves1, Ana Filipa Simão1, Mariana F P Graça2

  • 1University of Coimbra, CIEPQPF, Department of Chemical Engineering, Faculty of Sciences and Technology, Rua Sílvio Lima, 3030-790 Coimbra, Portugal.

Polymers
|January 17, 2024
PubMed
Summary
This summary is machine-generated.

Injectable hydrogels made from dextran, calcium triphosphate, and nanohydroxyapatite show promise for bone regeneration. These scaffolds offer antibacterial properties and suitable mechanical strength for treating bone infections and defects.

Keywords:
bone regenerationdrug releaseinjectable hydrogelsoxidized dextran

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Area of Science:

  • Biomaterials Science
  • Tissue Engineering
  • Orthopedic Surgery

Background:

  • Bone infections and injuries pose significant health challenges.
  • Conventional treatments for bone issues have limitations.
  • Injectable scaffolds offer a less invasive alternative for tissue regeneration.

Purpose of the Study:

  • To develop injectable hydrogel scaffolds for bone regeneration.
  • To create scaffolds with enhanced mechanical properties and antibacterial capabilities.
  • To provide a minimally invasive solution for bone defects and infections.

Main Methods:

  • Synthesized injectable hydrogels using dextran, calcium β-triphosphate, and nanohydroxyapatite.
  • Characterized hydrogels for swelling, degradation, and mechanical properties (Young's modulus).
  • Incorporated vancomycin for antibacterial effects and assessed drug release and cytotoxicity using osteoblasts.

Main Results:

  • Successfully synthesized dextran-based hydrogels with a Young's modulus of 200-300 kPa.
  • Hydrogels exhibited appropriate swelling and degradation profiles for bone regeneration timelines.
  • Demonstrated significant vancomycin release (50-80% burst) and fair biocompatibility with osteoblasts.

Conclusions:

  • Developed injectable hydrogels are suitable for bone regeneration applications.
  • The scaffolds possess mechanical strength, controlled degradation, and antibacterial properties.
  • These hydrogels are promising for treating bone infections and as antibiotic-eluting bone graft substitutes.