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Related Experiment Video

Updated: Jul 5, 2025

Endoscopic Endonasal Trans-sphenoidal Approach: Minimally Invasive Surgery for Pituitary Adenomas

Endoscopic Endonasal Trans-sphenoidal Approach: Minimally Invasive Surgery for Pituitary Adenomas

Published on: January 17, 2018

Metabolic Disorders During Prolactinomas.

Mouna Elleuch¹, Molka Ben Bnina¹, Fatma Loukil¹

¹Department of Endocrinolgy Diabetology, Hedi Chaker Hospital, University of Sfax, Sfax, Tunisia.

Metabolic Syndrome and Related Disorders

|January 17, 2024

Summary

Larger prolactinomas (pituitary tumors) are linked to increased obesity, glucose intolerance, and abnormal lipid levels. Early assessment and management of metabolic changes are crucial for patients with prolactinomas.

Keywords:

adenoma glucose level obesity prolactin waist circumference

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Area of Science:

Endocrinology
Metabolic Medicine
Oncology

Background:

Prolactinomas, a type of pituitary tumor, can significantly alter metabolic profiles.
Understanding these metabolic changes is essential for patient management.

Purpose of the Study:

To describe metabolic aspects in prolactinoma patients.
To investigate correlations between prolactinoma size and metabolic parameters.

Main Methods:

Retrospective study of 77 prolactinoma cases (2000-2017).
Patients grouped by tumor size.
Statistical analysis of clinical and biological parameters against tumor size.

Main Results:

Positive correlation between waist circumference and tumor size (r=0.29, P=0.019).
Obesity (72.7%) and android fat distribution were common.
Increased prolactinoma size correlated with glucose intolerance, hypertriglyceridemia, and decreased HDL cholesterol.

Conclusions:

Prolactinomas have significant metabolic and hormonal effects.
Metabolic syndrome is more prevalent in patients with larger prolactinomas.
Findings support tailored initial assessment and therapeutic strategies for prolactin adenomas.