Related Experiment Video
Updated: Jun 29, 2026

Noninvasive Assessment of Cardiac Abnormalities in Experimental Autoimmune Myocarditis by Magnetic Resonance Microscopy Imaging in the Mouse
Published on: June 20, 2014
Myocarditis in Minnehaha County, South Dakota, 1880-1939
Emily Petersen1, Lillian Schulte1, Hunter O'Connor1
1University of South Dakota Sanford School of Medicine.
An apparent rise in myocarditis cases in Minnehaha County from 1920-1940 was not real. Physician diagnostic term choice, not increased disease incidence, explains the observed trend in fatal and chronic myocarditis.
Area of Science:
- Cardiovascular Pathology
- Medical History
- Epidemiology
Background:
- An observed increase in myocarditis diagnoses occurred in Minnehaha County between 1920 and 1940.
- This trend included both fatal and chronic myocarditis cases.
Purpose of the Study:
- To investigate the cause of the apparent increase in myocarditis incidence in Minnehaha County during the specified period.
- To determine if the observed rise reflected actual disease prevalence or diagnostic practices.
Main Methods:
- Analysis of interment records from Mt. Pleasant Cemetery.
- Word frequency studies in two major American medical journals.
- Review of related medical publications from the era.
Main Results:
- No evidence suggests a genuine increase in inflammatory myocardial disorders in Minnehaha County.
- The observed increase in myocarditis diagnoses appears to stem from physician diagnostic choices.
- Local diagnostic terminology was not aligned with contemporary clinical and pathophysiologic literature.
Conclusions:
- The apparent rise in myocarditis incidence was an artifact of diagnostic terminology, not an epidemiological event.
- Physician discretion in applying diagnostic terms influenced the recorded frequency of myocarditis.
- Historical medical records require careful interpretation regarding diagnostic trends.
More Related Videos
09:16Isolation and Characterization of Cardiac Mesenchymal Stromal Cells from Endomyocardial Bioptic Samples of Arrhythmogenic Cardiomyopathy Patients
Published on: February 28, 2018
08:24Establishing a Swine Model of Post-myocardial Infarction Heart Failure for Stem Cell Treatment
Published on: May 25, 2020
Related Concept Videos
Myocarditis I: Introduction
Myocarditis II: Clinical Features and Diagnostic Tests
Myocarditis III: Medical Management
Myocarditis IV: Nursing Management
Rheumatic Heart Disease I: Introduction
Cardiomyopathy III: Hypertrophic Cardiomyopathy