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Silicon-Based Piezo Micropumps Enable Fully Flexible Drug Delivery Patterns.

David Plano1, Sebastian Kibler2, Niklas Rudolph1

  • 1Fraunhofer Institute for Translational Medicines and Pharmacology ITMP, Theodor-Stern-Kai 7, 60596 Frankfurt am Main, Germany.

Journal of Pharmaceutical Sciences
|January 17, 2024
PubMed
Summary

A new piezoelectric micropump enables precise and reproducible drug delivery. This innovative device offers flexible control over drug release profiles, paving the way for personalized medicine applications.

Keywords:
Acetaminophen (paracetamol)FingolimodMetoprololMicropumpProgrammable drug deliveryRelease profile

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Area of Science:

  • Biomedical Engineering
  • Materials Science
  • Pharmaceutical Sciences

Background:

  • Drug release precision is limited by current formulation methods.
  • Advanced drug delivery systems are needed for targeted therapy and optimal drug efficacy.
  • Existing approaches struggle with reproducibility due to excipient and API properties.

Purpose of the Study:

  • To evaluate a piezoelectric micropump for precise drug delivery.
  • To assess the pump's performance with both API solutions and suspensions.
  • To explore the potential for customized and programmable drug release profiles.

Main Methods:

  • Utilized a 5 × 5 × 0.6 mm³ piezoelectric micropump for drug delivery experiments.
  • Tested the micropump with solutions of highly soluble active pharmaceutical ingredients (APIs).
  • Investigated the delivery of suspensions with varying particle sizes and concentrations.

Main Results:

  • The micropump demonstrated high precision and reproducibility when delivering API solutions.
  • Pumping performance for suspensions was significantly influenced by particle size and concentration.
  • Flexible programming of release profiles was achieved with API solutions.

Conclusions:

  • The piezoelectric micropump provides a foundation for advanced drug delivery systems.
  • This technology enables customized and programmable drug release, advancing personalized medicine.
  • The device offers precise control over drug delivery, overcoming limitations of current formulations.