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Updated: Jul 5, 2025

Three-Dimensional Bone Extracellular Matrix Model for Osteosarcoma
Published on: April 12, 2019
Cemento-ossifying fibroma transforming to osteosarcoma
Naqoosh Haidry1, Peeyush Shivhare2, Ejaz Ahmad Mokhtar2
1Dentistry, All India Institute of Medical Sciences-Patna, Patna, Bihar, India naqoosh.haidry@gmail.com.
This study presents a rare case of cemento-ossifying fibroma transforming into osteosarcoma. Long-term radiographic evidence documents this unusual malignant transformation of a fibro-osseous lesion.
Area of Science:
- Oral and Maxillofacial Pathology
- Oncology
- Radiology
Background:
- Ossifying fibroma is a fibro-osseous lesion, with subtypes including cemento-ossifying fibroma.
- Malignant transformation of fibro-osseous lesions is rare, particularly for ossifying fibroma.
Observation:
- Presents an extremely rare case of cemento-ossifying fibroma.
- Details sequential radiographic findings over time.
Findings:
- Demonstrates the malignant transformation of cemento-ossifying fibroma into osteosarcoma.
- Highlights the scarcity of documented cases for this specific transformation.
Implications:
- Contributes to understanding the rare malignant potential of ossifying fibromas.
- Emphasizes the importance of long-term radiographic monitoring for fibro-osseous lesions.
- Provides valuable data for differential diagnosis and treatment strategies.
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