Related Experiment Video

Updated: Jul 5, 2025

Measuring Frailty in HIV-infected Individuals. Identification of Frail Patients is the First Step to Amelioration and Reversal of Frailty
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Measuring Frailty in HIV-infected Individuals. Identification of Frail Patients is the First Step to Amelioration and Reversal of Frailty

Published on: July 24, 2013

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Under-utilization of statins among people with HIV who were aged 40 years or older

Pei-Ying Wu1, Hsin-Yun Sun2, Yu-Shan Huang2

  • 1Center of Infection Control, National Taiwan University Hospital, Taipei, Taiwan.

Journal of Microbiology, Immunology, and Infection = Wei Mian Yu Gan Ran Za Zhi
|January 17, 2024
PubMed

Insights

Many people living with HIV have a high risk of atherosclerotic cardiovascular disease (ASCVD). While many qualified for statin therapy, a significant number did not receive prescriptions, indicating a gap in preventative care.

Area of Science:

  • Cardiology
  • Infectious Diseases
  • Public Health

Background:

  • HIV infection is associated with an increased risk of atherosclerotic cardiovascular disease (ASCVD).
  • Effective management of ASCVD risk factors is crucial for improving long-term outcomes in people with HIV.
  • Current guidelines recommend statin therapy for individuals with elevated ASCVD risk.

Purpose of the Study:

  • To assess the 10-year atherosclerotic cardiovascular disease (ASCVD) risk in a cohort of HIV-positive individuals.
  • To determine the proportion of participants eligible for statin therapy based on established risk criteria.
  • To evaluate the rate of statin prescription among eligible HIV-positive individuals.

Main Methods:

  • Prospective cohort study involving 1629 HIV-positive participants from June 2022 to April 2023.
  • Calculation of 10-year ASCVD risk using a validated risk assessment tool.
  • Analysis of statin eligibility criteria and prescription patterns.

Main Results:

  • The majority of participants (59.9%) had a low 10-year ASCVD risk (<5%).
  • A significant proportion (27.0%) met the criteria for statin therapy (≥7.5% risk).
  • Among those eligible for statins, only 38.8% were prescribed the therapy, highlighting a treatment gap.

Conclusions:

  • A notable percentage of HIV-positive individuals exhibit elevated ASCVD risk, warranting preventative interventions.
  • There is a significant underprescription of statin therapy among eligible HIV-positive individuals.
  • Addressing this gap in statin prescribing is essential for mitigating cardiovascular risk in this population.

Keywords:
Atherosclerotic cardiovascular diseaseDiabetes mellitusDyslipidemiaLipid-lowering agentMajor adverse cardiovascular eventNon-communicable disease

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