Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Overview of Exosomes01:36

Overview of Exosomes

2.7K
Exosomes are stable, lipid bilayer-enclosed vesicles capable of crossing biological barriers. They can carry a wide range of molecules required for intercellular communication. Once exosomes are released from the cell where they originated, they enter a recipient cell through various pathways such as fusion, receptor-mediated endocytosis, macropinocytosis, and phagocytosis.
Stahl et al. discovered exosomes in 1983, but the exosomes were initially considered waste products released from the...
2.7K
Insulin Secretory Vesicles01:05

Insulin Secretory Vesicles

5.0K
Insulin secretory vesicles release insulin to stimulate blood glucose uptake and regulate carbohydrate metabolism. When the blood glucose levels increase, glucose enters the pancreatic β-islet cells through glucose transporters. Once inside, glucose is metabolized through glycolysis, the citric acid cycle, and the electron transport chain, producing ATP. This increase in ATP concentration closes ATP-sensitive potassium channels, leading to depolarization of the membrane and the opening of...
5.0K
Pathophysiology of Diabetes01:20

Pathophysiology of Diabetes

940
Diabetes mellitus is a chronic metabolic disorder characterized by hyperglycemia. The four categories of diabetes are type 1 diabetes, type 2 diabetes, other specific types of diabetes, and gestational diabetes.
Type 1 diabetes is characterized by autoimmune-mediated destruction of pancreatic β cells, with environmental factors potentially triggering this process in genetically susceptible individuals. Despite many not having a family history, certain genes increase susceptibility,...
940
Psychoneuroimmunology: Diabetes and Cancer01:19

Psychoneuroimmunology: Diabetes and Cancer

29
Chronic stress has been linked to both the onset and progression of serious health conditions, including Type 2 diabetes and cancer. Type 2 diabetes, a widespread chronic illness, is closely associated with obesity and insulin resistance, both of which often worsen under stress. Studies indicate that men experiencing high levels of chronic stress face a 45% higher risk of developing diabetes compared to those with minimal stress. Stress triggers physiological responses that elevate blood...
29
Diabetes Mellitus: Overview and Type I Subtype01:22

Diabetes Mellitus: Overview and Type I Subtype

2.6K
Diabetes mellitus is a chronic metabolic disorder characterized by high blood glucose levels due to inadequate insulin production, insulin resistance, or both. The condition affects millions worldwide and can significantly impact their health and quality of life.
Type 1 diabetes is an autoimmune disease in which the immune system mistakenly attacks and destroys the insulin-producing beta cells in the pancreas. As a result, the body is unable to produce sufficient insulin, and individuals with...
2.6K
The Endocrine System01:29

The Endocrine System

296
The endocrine system is an extensive network of glands – organs or tissues in the body that create chemicals that control many bodily functions, that secrete hormones, which are chemical messengers that play essential roles in regulating various bodily functions. These hormones are secreted into the bloodstream and travel throughout the body. They require specific receptors to convey signals to cells possessing these corresponding receptors. This complex signaling mechanism ensures that...
296

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

A straightforward access to specific bisindole systems related to caulersin.

Organic & biomolecular chemistry·2026
Same author

Postoperative anlotinib plus radiotherapy in patients with newly diagnosed, unmethylated O<sup>6</sup>-methylguanine-DNA methyltransferase glioblastoma: A single-arm, phase 2 study.

Cancer·2026
Same author

A Multi-Scale Edge-Preserving Decomposition and Fusion Framework for Multi-Polarization Passive Millimeter-Wave Imaging.

Sensors (Basel, Switzerland)·2026
Same author

Assessing climate-driven treeline dynamics via the habitat suitability index.

Journal of environmental management·2026
Same author

Chikusetsu saponin IVa mitigates septic cardiac injury by targeting DRP1 to suppress mitochondrial damage and NLRP3 inflammasome activation.

Life sciences·2026
Same author

Immunological research landscapes and emerging immune mechanisms in HIV/HBV co-infection: a bibliometric analysis (2014-2024).

Frontiers in immunology·2026
Same journal

Papillary thyroid carcinoma discovered in a patient on semaglutide therapy for metabolic syndrome: a case presentation and review of current evidence.

Hormones (Athens, Greece)·2026
Same journal

Non-invasive imaging diagnostic techniques in metabolic dysfunction-associated steatotic liver disease: a roadmap for clinicians.

Hormones (Athens, Greece)·2026
Same journal

Association between serum vitamins and sex hormone levels in adolescent males: based on the National Health and Nutrition Examination Survey (NHANES).

Hormones (Athens, Greece)·2026
Same journal

Global trends in the prevalence of type 2 diabetes mellitus: understanding trajectories through conceptual frameworks.

Hormones (Athens, Greece)·2026
Same journal

Advances in diabetes technology: clinical implications, limitations, and future perspectives.

Hormones (Athens, Greece)·2026
Same journal

Associations between multiple metabolic indices and circadian syndrome: a cross-sectional study with mediation analysis of the C-reactive protein triglyceride glucose index.

Hormones (Athens, Greece)·2026
See all related articles

Related Experiment Video

Updated: Jul 5, 2025

Isolation, Characterization, and Therapeutic Application of Extracellular Vesicles from Cultured Human Mesenchymal Stem Cells
07:03

Isolation, Characterization, and Therapeutic Application of Extracellular Vesicles from Cultured Human Mesenchymal Stem Cells

Published on: September 23, 2022

2.1K

How does exosome cause diabetes?

Fei Hu1, Yicong Yu2, Hongming Xu3

  • 1Cixi Biomedical Research Institute, Wenzhou Medical University, Cixi, Ningbo, China.

Hormones (Athens, Greece)
|January 17, 2024
PubMed
Summary
This summary is machine-generated.

Exosomes, tiny vesicles involved in cell communication, play a key role in diabetes development. Understanding exosome function offers new diagnostic and therapeutic strategies for diabetes.

Keywords:
DiabetesExosomeInsulin resistanceβ-cells

More Related Videos

Preparation of Exosomes for siRNA Delivery to Cancer Cells
09:59

Preparation of Exosomes for siRNA Delivery to Cancer Cells

Published on: December 5, 2018

25.1K
Purification and Transplantation of Myogenic Progenitor Cell Derived Exosomes to Improve Cardiac Function in Duchenne Muscular Dystrophic Mice
08:13

Purification and Transplantation of Myogenic Progenitor Cell Derived Exosomes to Improve Cardiac Function in Duchenne Muscular Dystrophic Mice

Published on: April 10, 2019

6.1K

Related Experiment Videos

Last Updated: Jul 5, 2025

Isolation, Characterization, and Therapeutic Application of Extracellular Vesicles from Cultured Human Mesenchymal Stem Cells
07:03

Isolation, Characterization, and Therapeutic Application of Extracellular Vesicles from Cultured Human Mesenchymal Stem Cells

Published on: September 23, 2022

2.1K
Preparation of Exosomes for siRNA Delivery to Cancer Cells
09:59

Preparation of Exosomes for siRNA Delivery to Cancer Cells

Published on: December 5, 2018

25.1K
Purification and Transplantation of Myogenic Progenitor Cell Derived Exosomes to Improve Cardiac Function in Duchenne Muscular Dystrophic Mice
08:13

Purification and Transplantation of Myogenic Progenitor Cell Derived Exosomes to Improve Cardiac Function in Duchenne Muscular Dystrophic Mice

Published on: April 10, 2019

6.1K

Area of Science:

  • Cell Biology
  • Endocrinology
  • Immunology

Background:

  • Exosomes are extracellular vesicles facilitating intercellular communication.
  • They are implicated in various physiological and pathological processes.
  • Exosomes are increasingly recognized for their role in diabetes pathogenesis.

Purpose of the Study:

  • To review the multifaceted role of exosomes in the development of diabetes.
  • To highlight exosome involvement in key diabetes-related mechanisms.
  • To explore the potential of exosomes in diabetes diagnosis and treatment.

Main Methods:

  • Literature review of studies on exosomes and diabetes.
  • Analysis of exosome content and function in diabetes models.
  • Synthesis of current research on exosome-mediated intercellular signaling in diabetes.

Main Results:

  • Exosomes contribute to diabetes by promoting beta-cell apoptosis.
  • They are involved in activating autoimmune responses against pancreatic islets.
  • Exosomes modulate cytokine profiles, impacting islet function and insulin sensitivity.

Conclusions:

  • Exosomes are critical mediators in the pathogenesis of diabetes.
  • Targeting exosome pathways presents a promising avenue for novel diabetes therapies.
  • Further research into exosome biology can lead to innovative diagnostic tools for diabetes.