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Clinical prognostic impact of C-NLR in heart failure patients with different ejection fractions: a retrospective
Fazhi Yang1, Lihua Zhang2, Wei Huang3
1Department of Cardiology, Kunming Medical University First Affilliated Hospital, City, Kunming, Yunnan Province, China.
Insights
The C-NLR index, combining C-reactive protein and neutrophil-to-lymphocyte ratio, effectively predicts mortality risk in chronic heart failure (CHF) patients. This new indicator aids clinicians in identifying high-risk individuals for better prognosis management.
Area of Science:
- Cardiology
- Immunology
- Biomarker Research
Background:
- Inflammatory conditions and immune disorders negatively impact chronic heart failure (CHF) patient prognosis.
- Identifying reliable prognostic markers is crucial for managing CHF patients.
Purpose of the Study:
- To evaluate the prognostic value of a novel C-NLR index for all-cause mortality risk in heart failure (HF) patients.
- To assess C-NLR in HF patients across different ejection fraction categories.
Main Methods:
- 1221 CHF patients were enrolled; data collected from January 2017 to October 2021.
- Patients were stratified by median C-NLR levels. Kaplan-Meier curves and Cox proportional hazards models were used.
- Receiver operating characteristic (ROC) analyses assessed the predictive value of C-NLR.
Main Results:
- Analysis included 1192 CHF patients.
- Kaplan-Meier analysis indicated better overall survival in patients with lower C-NLR.
- Multivariate Cox analysis confirmed C-NLR as an independent predictor of mortality.
Conclusions:
- C-NLR is a competent independent predictor of mortality in HF patients with varying ejection fractions.
- Routine C-NLR measurement can assist clinicians in identifying patients with a poor prognosis.
Objection:
Inflammatory conditions and immune disorders may worsen the prognosis of chronic heart failure (CHF) patients. The aim of this study was to evaluate the prognostic value of a new indicator, C-NLR, composed of C-reactive protein (CRP) and neutrophil-to-lymphocyte ratio (NLR), for the risk of all-cause mortality in HF patients with different ejection fractions.
Methods:
A total of 1221 CHF patients admitted to the First Affiliated Hospital of Kunming Medical University from January 2017 to October 2021 were enrolled in this study. All patients were divided into 2 groups according to the median C-NLR. Kaplan-Meier survival curves were used to compare the all-cause mortality among CHF patients with different ejection fractions. Cox proportional hazards analysis was used to evaluate the relationships between variables and mortality. The predictive value of the C-NLR was assessed by using receiver operating characteristic (ROC) analyses.
Results:
We collected data from 1192 patients with CHF. Kaplan-Meier survival analysis revealed that patients with low LCR levels had better overall survival (OS). After multivariate adjustment Cox proportional hazards analysis, the level of C-NLR was still independently related to mortality.
Conclusions:
C-NLR was a competent independent predictor in HF with different ejection fractions, and routine measurement of C-NLR would help clinical doctors identify patients with a poor prognosis.
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