[Mathematical model of interphase cell death. Biophysical justification and generalization]

The authors propose a biophysical justification of a radiation-induced injury and interphase death of cells. The injury to certain units of the microtrabecular network and cytoskeleton is considered to be a primary biological effect of radiation on cells. The role of these structural changes in the development of the specific radiation response is discussed. It is found possible to describe formally, by the defined parameters of the proposed model, the survival curves for not only interphase but also reproductive cell death.