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Updated: Oct 7, 2026

Study of In Vivo Glucose Metabolism in High-fat Diet-fed Mice Using Oral Glucose Tolerance Test OGTT and Insulin Tolerance Test ITT
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Study of In Vivo Glucose Metabolism in High-fat Diet-fed Mice Using Oral Glucose Tolerance Test OGTT and Insulin Tolerance Test ITT

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Recent progress in metabolic reprogramming in gestational diabetes mellitus: a review

Ya-Ping Xie1, Shu Lin2,3, Bao-Yuan Xie1

  • 1Nursing Department, The Second Affiliated Hospital of Fujian Medical University, Quanzhou, Fujian, China.

Frontiers in Endocrinology
|January 18, 2024
PubMed

Gestational diabetes mellitus is a prevalent metabolic disease that can impact the normal course of pregnancy and delivery, leading to adverse outcomes for both mother and child. Its pathogenesis is complex and involves various factors, such as insulin resistance and β-cell dysfunction. Metabolic reprogramming, which involves mitochondrial oxidative phosphorylation and glycolysis, is crucial for maintaining human metabolic balance and is involved in the pathogenesis and progression of gestational diabetes mellitus. However, research on the link and metabolic pathways between metabolic reprogramming and gestational diabetes mellitus is limited. Therefore, we reviewed the relationship between metabolic reprogramming and gestational diabetes mellitus to provide new therapeutic strategies for maternal health during pregnancy and reduce the risk of developing gestational diabetes mellitus.

Keywords:
blood glucosegestational diabetes mellitusmetabolic reprogrammingmitochondrial oxidative phosphorylationpathophysiology

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