Utility of a Synthetic Hybrid-Scale Fiber Matrix in Surgical Soft Tissue Reconstruction

Large wounds, regardless of etiology, can be difficult to close and often require advanced treatment. The complexity of healing these wounds increases when underlying structures such as tendon and muscle are exposed. These structures are difficult to granulate tissue over, and successful wound closure, whether through secondary intention or via a split-thickness skin graft or flap, is dependent on sufficient coverage of the exposed bone or tendon. Given these challenges, new treatment options should be explored to achieve successful outcomes in this patient population. A resorbable synthetic hybrid-scale fiber matrix, with a structure similar to that of native human extracellular matrix, is gaining popularity in the treatment of soft tissue defects.

A retrospective case series was conducted via review of medical charts. Patients included in this review were treated with the synthetic hybrid-scale fiber matrix to manage large, deep wounds with exposed structures. Twenty-two patients with deep surgical wounds of various etiologies were treated with the synthetic hybrid-scale fiber matrix to granulate the wound bed in preparation for a split-thickness skin graft or flap closure or until complete re-epithelialization of the wound.

The average patient age was 59.3 years old, and the average initial wound size was 210.3 cm^². All wounds had exposed structures, which included muscle, fat, fascia, or tendon. Wounds were closed utilizing healing by secondary intent (23%), bridging to a split-thickness skin graft (63%), or bridging to a flap closure (14%). All wounds achieved total closure within an average of 41.4 days with no reported complications.

The synthetic hybrid-scale fiber matrix demonstrated efficacy encouraging granulation tissue over exposed structures and should be considered as a novel treatment option for complex soft tissue reconstruction.