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Updated: Jul 5, 2025
Quantifying the Brain Metastatic Tumor Micro-Environment using an Organ-On-A Chip 3D Model, Machine Learning, and Confocal Tomography
Published on: August 16, 2020
Decoding mTOR signalling heterogeneity in the tumour microenvironment using multiplexed imaging and graph
Investigating tumor microenvironment (TME) complexity using multiplexed imaging reveals heterogeneous mTOR signaling patterns in colorectal cancer. These patterns in tumor and immune cells significantly impact patient prognosis, offering new therapeutic targets.
Area of Science:
- Oncology
- Immunology
- Bioinformatics
Background:
- The tumor microenvironment (TME) plays a critical role in cancer progression, but its complexity makes it challenging to study.
- Multiplexed imaging enables simultaneous assessment of multiple TME components, offering a powerful tool for deeper investigation.
Conclusions:
- Complex mTOR signaling within the tumor microenvironment significantly influences colorectal cancer patient outcomes.
- This study provides a framework for analyzing intricate cell signaling in cancer.
- Findings offer crucial insights for the development of novel mTOR-based therapeutic strategies.
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