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mTOR Signaling and Cancer Progression

mTOR Signaling and Cancer Progression

The mammalian target of rapamycin or mTOR protein was discovered in 1994 due to its direct interaction with rapamycin. The protein gets its name from a yeast homolog called TOR. The mTOR protein complex in mammalian cells plays a major role in balancing anabolic processes such as the synthesis of proteins, lipids, and nucleotides and catabolic processes, such as autophagy in response to environmental cues, such as availability of nutrients and growth factors.
The mTOR pathway or the...

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Related Experiment Video

Updated: Jul 5, 2025

Quantifying the Brain Metastatic Tumor Micro-Environment using an Organ-On-A Chip 3D Model, Machine Learning, and Confocal Tomography

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Decoding mTOR signalling heterogeneity in the tumour microenvironment using multiplexed imaging and graph

Razan Zuhair, Mark Eastwood, Megan Jones

Biorxiv : the Preprint Server for Biology

|January 18, 2024

Summary

Investigating tumor microenvironment (TME) complexity using multiplexed imaging reveals heterogeneous mTOR signaling patterns in colorectal cancer. These patterns in tumor and immune cells significantly impact patient prognosis, offering new therapeutic targets.

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Last Updated: Jul 5, 2025

Quantifying the Brain Metastatic Tumor Micro-Environment using an Organ-On-A Chip 3D Model, Machine Learning, and Confocal Tomography

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Published on: August 16, 2020

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Published on: June 2, 2023

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Area of Science:

Oncology
Immunology
Bioinformatics

Background:

The tumor microenvironment (TME) plays a critical role in cancer progression, but its complexity makes it challenging to study.
Multiplexed imaging enables simultaneous assessment of multiple TME components, offering a powerful tool for deeper investigation.

Conclusions:

Complex mTOR signaling within the tumor microenvironment significantly influences colorectal cancer patient outcomes.
This study provides a framework for analyzing intricate cell signaling in cancer.
Findings offer crucial insights for the development of novel mTOR-based therapeutic strategies.