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Coupling Bacterial Cell Size Regulation with Clonal Proliferation Dynamics Reveals Cell Division Based on Surface
César Nieto1, Sarah Täuber2,3, Luisa Blöbaum2,3
1Department of Electrical and Computing Engineering, University of Delaware. Newark, DE 19716, USA.
Biorxiv : the Preprint Server for Biology
|January 18, 2024
Summary
Cell size control, specifically the adder strategy, stabilizes colony size over generations, unlike timer models. This finding impacts understanding microbial population growth and size homeostasis.
Area of Science:
- Microbiology
- Cell Biology
- Mathematical Biology
Background:
- Single cells regulate size through growth and division, but how this impacts population expansion over generations is unknown.
- Classical 'timer' models predict increasing colony size variation, while 'adder' models suggest eventual stabilization.
Conclusions:
- Integrated mathematical modeling and experimental validation reveal mechanisms of size homeostasis in microbial colonies.
- Stochastic dynamics of colony size elucidate single-cell size regulation and its population-level consequences.
- The study bridges single-cell size control and clonal expansion dynamics for rod-shaped microbes.
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