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Chronic subthreshold cortical stimulation: A promising therapy for motor cortex seizures
Sebastien Heyndrickx1, Simon Lamquet1, Joyce Oerlemans1
1Department of Neurology, Ghent University Hospital, Ghent, Belgium.
Epilepsy & Behavior Reports
|January 18, 2024
Summary
Chronic subthreshold cortical stimulation (CSCS) offers a potential long-term treatment for drug-resistant epilepsy. This case study shows CSCS significantly improved a patient's debilitating focal motor seizures, enabling unaided walking.
Area of Science:
- Neuroscience
- Neurology
- Biomedical Engineering
Background:
- Focal drug-resistant epilepsy poses significant challenges for long-term management.
- Chronic subthreshold cortical stimulation (CSCS) is an underutilized neurostimulation technique targeting the epileptogenic zone (EZ).
- The motor cortex is a critical area where EZ localization can complicate treatment options.
Observation:
- A 49-year-old female patient presented with severe, debilitating focal motor seizures.
- The patient's EZ was identified, making her a candidate for targeted neurostimulation.
- Previous treatments had not provided sufficient seizure control.
Findings:
- Treatment with CSCS demonstrated significant clinical improvement in seizure frequency and severity.
- The patient experienced a remarkable recovery, regaining the ability to walk unaided.
- CSCS proved to be a safe and effective intervention in this case.
Implications:
- CSCS presents a promising therapeutic option for focal drug-resistant epilepsy, particularly when the EZ is in the motor cortex.
- This case highlights the potential of CSCS for improving quality of life and functional independence in epilepsy patients.
- Further research into CSCS efficacy and patient selection is warranted for broader clinical application.
