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Prodrugs

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Prodrugs are a class of pharmaceutical compounds that undergo a biotransformation process within the body to be converted into a pharmacologically active drug. Prodrugs are designed to improve the therapeutic properties of the parent drug, such as enhancing bioavailability, increasing stability, or reducing toxicity. The concept of prodrugs revolves around modifying the chemical structure of the original drug to make it more effective or convenient for administration.
Prodrugs help overcome...
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Drugs, the chemical agents used in diagnosing, treating, or preventing diseases, undergo a four-phase process of development: pharmaceutic, pharmacokinetics, pharmacodynamics, and therapeutic.
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Solid dosage forms such as tablets and capsules undergo rigorous manufacturing processes to ensure stability and effectiveness. Their dissolution and absorption properties are influenced significantly by the choice of excipients (inactive ingredients that serve various roles in the formulation), and the methodology applied during production. The manufacturing parameters, such as compression force and granulation techniques, significantly affect dissolution rates. Elevated compression forces...
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Preclinical development consists of a series of tests that ensure the safety and efficacy of a new therapeutic compound before it is tested in humans. There are four main phases to this process. First, safety pharmacology tests are conducted to ensure the drug does not produce any acutely harmful effects. These tests examine parameters such as bronchoconstriction, cardiac dysrhythmias, blood pressure changes, and ataxia. Next, preliminary toxicological testing is performed to determine the...
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PharmaPy: An object-oriented tool for the development of hybrid pharmaceutical flowsheets.

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  • 1Davidson School of Chemical Engineering, Purdue University, West Lafayette, IN 47906, USA.

Computers & Chemical Engineering
|January 18, 2024
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Summary

This study introduces PharmaPy, a Python-based platform for pharmaceutical manufacturing systems design and optimization. PharmaPy enhances digital design and simulation for both continuous and batch pharmaceutical processes.

Keywords:
Digital designFlowsheet simulationHybrid processesOptimizationParameter estimationPharmaceutical process simulatorPython

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Area of Science:

  • Chemical Engineering
  • Process Systems Engineering
  • Computational Modeling

Background:

  • Traditional chemical process simulation tools are insufficient for complex pharmaceutical manufacturing.
  • Developing advanced digital design and optimization platforms is crucial for the pharmaceutical industry.

Purpose of the Study:

  • Introduce PharmaPy, a novel Python-based modeling platform tailored for pharmaceutical manufacturing.
  • Demonstrate the platform's capability in simulating and optimizing both continuous and batch pharmaceutical processes.

Main Methods:

  • Development of a versatile Python-based modeling platform, PharmaPy.
  • Application of PharmaPy to simulate and optimize pharmaceutical manufacturing systems.
  • Illustrative examples showcasing the platform's key features and framework.

Main Results:

  • PharmaPy provides a flexible framework for pharmaceutical process design and optimization.
  • The platform effectively handles both continuous and batch processing simulations.
  • Key features and framework of PharmaPy are presented through practical examples.

Conclusions:

  • PharmaPy offers a powerful and adaptable solution for pharmaceutical manufacturing systems engineering.
  • The platform addresses the need for specialized tools in pharmaceutical process design and optimization.
  • PharmaPy is poised to advance computational challenges in pharmaceutical manufacturing.