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PharmaPy: An object-oriented tool for the development of hybrid pharmaceutical flowsheets

Daniel Casas-Orozco¹, Daniel Laky¹, Vivian Wang²

¹Davidson School of Chemical Engineering, Purdue University, West Lafayette, IN 47906, USA.

Computers & Chemical Engineering

|January 18, 2024

Abstract:

Process design and optimization continue to provide computational challenges as the chemical engineering and process optimization communities seek to address more complex and larger scale applications. Software tools for digital design and flowsheet simulation are readily available for traditional chemical processing applications such as in commodity chemicals and hydrocarbon processing; however, tools for pharmaceutical manufacturing are much less well developed. This paper introduces, PharmaPy, a Python-based modelling platform for pharmaceutical manufacturing systems design and optimization. The versatility of the platform is demonstrated in simulation and optimization of both continuous and batch processes. The structure and features of a Python-based modeling platform, PharmaPy are presented. Illustrative examples are shown to highlight key features of the platform and framework.

Keywords:

Digital design Flowsheet simulation Hybrid processes Optimization Parameter estimation Pharmaceutical process simulator Python

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