Related Experiment Video
Updated: Jul 5, 2025
Isolating Human Peripheral Blood Mononuclear Cells and CD4+ T cells from Sézary Syndrome Patients for Transcriptomic Profiling
Published on: October 14, 2021
Bilateral peripheral ulcerative keratitis in a patient with known Sézary syndrome
Michael J Maywood1, David G Heidemann1, Chirag K Gupta1
1Department of Ophthalmology, Corewell Health William Beaumont University Hospital, 3535 W. 13 Mile Rd #555, Royal Oak, MI, 48073, USA.
Purpose:
To report a case of bilateral peripheral ulcerative keratitis (PUK) in a patient with underlying Sézary syndrome.
Observations:
A 58-year-old male presented with bilateral corneal ulceration with stromal thinning and was diagnosed with PUK. He was actively being treated for Sézary syndrome, a cutaneous T-cell lymphoma. He had no lagophthalmos or other adnexal abnormalities that would lead to ocular surface breakdown. A systemic autoimmune and infectious workup for PUK was unremarkable. His keratitis resolved after treatment with oral prednisone.
Conclusions And Importance:
We describe a previously undocumented association of PUK with Sézary syndrome in a patient without adnexal disease.
