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Krestine Rosager Hansen¹, Jesper Kjærgaard¹, Helene Kvistgaard²

¹Afdeling for Børn og Unge, Københavns Universitetshospital - Rigshospitalet.

Ugeskrift for Laeger

|January 18, 2024

Summary

This summary is machine-generated.

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Treating chronic hepatitis C (HCV) in children with direct-acting antivirals (DAA) offers improved efficacy and safety. Early detection and treatment are recommended to prevent severe liver disease and transmission.

Area of Science:

Pediatric Gastroenterology and Hepatology
Infectious Diseases
Pharmacology

Background:

Chronic hepatitis C virus (HCV) infection in children can lead to serious liver complications like fibrosis, cirrhosis, and cancer.
Historically, HCV treatment options for children were limited, with lower efficacy and more side effects.
Recent advancements include the development and approval of direct-acting antiviral (DAA) medications for pediatric HCV treatment.

Conclusions:

Direct-acting antiviral (DAA) therapy represents a significant advancement in the management of chronic hepatitis C (HCV) in children.
Active case finding and prompt treatment are essential to mitigate the risk of liver disease progression and onward transmission.
Continued research and surveillance are necessary to optimize pediatric HCV care and eradication strategies.

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