Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Opioid Analgesics: Synthetic and Semisynthetic Opioids01:15

Opioid Analgesics: Synthetic and Semisynthetic Opioids

300
Synthetic and semisynthetic opioids are pivotal in pain management and tackling opioid addiction. Semisynthetic opioids, including morphinans (morphine derivatives), oxycodone, oxymorphone, hydrocodone, and hydromorphone, have improved pharmacokinetic profiles compared to morphine. Additionally, heroin and 6-MAM (6-Monoacetylmorphine) show better CNS penetration than morphine due to heightened lipid solubility. Hydromorphone, a potent opioid, undergoes hepatic metabolism to form the active...
300
Opioid Analgesics: Morphine and Other Natural Cogeners01:20

Opioid Analgesics: Morphine and Other Natural Cogeners

251
Opioids are a class of drugs that mimic endogenous opioid peptides and act on opioid receptors, and help in pain relief. These compounds are classified as natural, synthetic, or semi-synthetic. Natural opioids, like morphine, codeine, and thebaine, are derived from the opium poppy plant (Papaver somniferum or Papaver album) and are termed opiates. Synthetic opioids are artificial, while semi-synthetic opioids combine natural and synthetic compounds. Morphine, a prototypical opioid, possesses a...
251
Analgesia and Pain Management01:25

Analgesia and Pain Management

625
Pain is critical to various clinical pathologies, provoking an urgent need for effective management. Pain, whether acute or chronic, is a complex neurochemical process. Its alleviation depends on the type, with nonopioid analgesics effective for mild to moderate pain, such as musculoskeletal or inflammatory pain, while neuropathic pain responds best to anticonvulsants, tricyclic antidepressants, or serotonin/norepinephrine reuptake inhibitors. For severe acute or chronic pain, opioids may be...
625
Endoscopic Procedures IV: Sigmoidoscopy and Laproscopy01:26

Endoscopic Procedures IV: Sigmoidoscopy and Laproscopy

88
Sigmoidoscopy and laparoscopy are distinct medical procedures that enable physicians to internally inspect different parts of the GI tract. Although they serve different purposes, each is essential for diagnosing and, in some cases, treating various medical conditions.
Sigmoidoscopy
Sigmoidoscopy is a diagnostic procedure that uses a flexible sigmoidoscope equipped with a light source and camera to examine the rectum and sigmoid colon. The procedure involves inserting the tube through the anus...
88
General Anesthesia: Overview01:24

General Anesthesia: Overview

219
Anesthesia is a medical procedure that uses drugs for CNS suppression to enable painless surgeries and procedures. The selection of anesthetics is influenced by their pharmacokinetic properties, side effects, and patient characteristics. Various types of anesthesia include general, local, regional, spinal, and inhalational.
General anesthesia induces unconsciousness in the whole body, while the others target specific areas or sensations. It is administered to minimize adverse effects, maintain...
219
Heart Failure Drugs: Inhibitors of Renin-Angiotensin System01:26

Heart Failure Drugs: Inhibitors of Renin-Angiotensin System

432
The activation of the sympathetic nervous system and the renin-angiotensin-aldosterone system (RAAS) contributes to cardiac remodeling, and inhibiting the RAAS is a pharmacological target in heart failure management. As a result, neurohumoral modulation is a crucial treatment principle for managing heart failure. This approach involves using medications like ACE inhibitors (ACEIs), angiotensin receptor blockers (ARBs), β-blockers, mineralocorticoid receptor antagonists (MRAs), and neutral...
432

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Multi-fluid multi-species models for inverse first ionization potential effect.

Philosophical transactions. Series A, Mathematical, physical, and engineering sciences·2026
Same author

Evolution of solar and stellar coronal abundances owing to magnetic activity.

Philosophical transactions. Series A, Mathematical, physical, and engineering sciences·2026
Same author

The connection between solar coronal abundances and the underlying lower atmospheric properties.

Philosophical transactions. Series A, Mathematical, physical, and engineering sciences·2026
Same author

Sulfur fractionation in coronal plumes as observed by Solar Orbiter/Spectral Imaging of the Coronal Environment.

Philosophical transactions. Series A, Mathematical, physical, and engineering sciences·2026
Same author

Radiative hydrodynamic simulations of first ionization potential fractionation in solar flares.

Philosophical transactions. Series A, Mathematical, physical, and engineering sciences·2026
Same author

Exploring the link between wave activity in the photospheric velocity driver and the FIP bias in the solar corona.

Philosophical transactions. Series A, Mathematical, physical, and engineering sciences·2026
Same journal

A low-cost approach to national surveys of the nurse practitioner workforce in a resource-constrained environment.

Journal of the American Association of Nurse Practitioners·2026
Same journal

Drug pricing policy and its impact on clinical practice.

Journal of the American Association of Nurse Practitioners·2026
Same journal

From curiosity to clinical relevance: Rethinking genetic mosaicism.

Journal of the American Association of Nurse Practitioners·2026
Same journal

Preclinical objective structured clinical examination for Family Nurse Practitioner students: Impact on clinical confidence and perceptions of curricular integration.

Journal of the American Association of Nurse Practitioners·2026
Same journal

Under fire: Federal policy shifts and the impact on gender minority college students.

Journal of the American Association of Nurse Practitioners·2026
Same journal

Metastatic pleural mesothelioma presenting as ulcerated submucosal colonic nodules.

Journal of the American Association of Nurse Practitioners·2026
See all related articles

Related Experiment Video

Updated: Jul 5, 2025

Surgical Swine Model of Chronic Cardiac Ischemia Treated by Off-Pump Coronary Artery Bypass Graft Surgery
09:12

Surgical Swine Model of Chronic Cardiac Ischemia Treated by Off-Pump Coronary Artery Bypass Graft Surgery

Published on: March 27, 2018

9.5K

Implementing an evidence-based guideline to decrease opioids after cardiac surgery.

Roberto Galao-Malo1, Alison Davidson1, Rita D'Aoust2

  • 1Department of Cardiovascular Surgery, Mount Sinai Hospital, New York, New York.

Journal of the American Association of Nurse Practitioners
|January 18, 2024
PubMed
Summary
This summary is machine-generated.

This quality improvement project successfully reduced opioid overprescription in cardiac surgery patients by increasing acetaminophen use and limiting opioid discharge prescriptions. The intervention significantly decreased opioid tablets and morphine milligram equivalents (MME) at discharge.

More Related Videos

A Chronic Cardiac Ischemia Model in Swine Using an Ameroid Constrictor
08:22

A Chronic Cardiac Ischemia Model in Swine Using an Ameroid Constrictor

Published on: October 9, 2017

10.6K
An Experimental Paradigm for the Prediction of Post-Operative Pain PPOP
14:56

An Experimental Paradigm for the Prediction of Post-Operative Pain PPOP

Published on: January 27, 2010

21.4K

Related Experiment Videos

Last Updated: Jul 5, 2025

Surgical Swine Model of Chronic Cardiac Ischemia Treated by Off-Pump Coronary Artery Bypass Graft Surgery
09:12

Surgical Swine Model of Chronic Cardiac Ischemia Treated by Off-Pump Coronary Artery Bypass Graft Surgery

Published on: March 27, 2018

9.5K
A Chronic Cardiac Ischemia Model in Swine Using an Ameroid Constrictor
08:22

A Chronic Cardiac Ischemia Model in Swine Using an Ameroid Constrictor

Published on: October 9, 2017

10.6K
An Experimental Paradigm for the Prediction of Post-Operative Pain PPOP
14:56

An Experimental Paradigm for the Prediction of Post-Operative Pain PPOP

Published on: January 27, 2010

21.4K

Area of Science:

  • Cardiovascular Surgery
  • Pain Management
  • Public Health

Background:

  • Opioid overdose deaths are rising in the U.S., with overprescription after surgery being a contributing factor.
  • Opioid prescribing practices for cardiovascular surgery patients lack consistency, and discharge recommendations are not fully implemented.

Purpose of the Study:

  • To decrease opioid overprescription in adult patients undergoing elective cardiac surgery.
  • To improve pain management strategies by increasing acetaminophen use and reducing opioid quantities at discharge.

Main Methods:

  • A single-center, pre-post quality improvement project was conducted on adult patients after elective cardiac surgery via sternotomy.
  • Interventions included guideline changes, modified order sets, dashboards, and provider education to promote scheduled acetaminophen and limit opioid prescriptions.

Main Results:

  • Acetaminophen use on the step-down unit increased from 9% to 96% (p < .001).
  • The proportion of patients discharged with ≤25 opioid tablets rose from 18% to 90% (p < .001).
  • Discharge opioid prescriptions of ≤25 morphine milligram equivalents (MME) increased from 30% to 55% (p < .01), with acetaminophen prescription at discharge rising from 10% to 48% (p < .001).

Conclusions:

  • The quality improvement initiative effectively increased acetaminophen utilization and reduced opioid overprescription in cardiac surgery patients.
  • Further research is needed to optimize pain management protocols and minimize opioid prescribing at discharge.